Phenotypes associated with this allele

• Allele Symbol: Tg(RP11-209M4)AGglo
• Allele Name: transgene insertion A, Gabriela G Loots
• Allele ID: MGI:5304449
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(RP11-209M4)AGglo/Tg(RP11-209M4)AGglo	FVB-Tg(RP11-209M4)4Gglo	MGI:5304474
tg2	Tg(RP11-209M4)AGglo/0	FVB-Tg(RP11-209M4)4Gglo	MGI:5304472
tg3	Tg(RP11-209M4)AGglo/0	involves: C57BL/6 * FVB	MGI:5304493

Genotype
MGI:5304474

tg1

• Allelic Composition: Tg(RP11-209M4)AGglo/Tg(RP11-209M4)AGglo
• Genetic Background: FVB-Tg(RP11-209M4)4Gglo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal phalanx morphology ( J:179873 )

• mice exhibit a wide range of fused and missing digits

fused phalanges ( J:179873 )

decreased bone volume ( J:179873 )

• to a greater extent than in mice hemizygous for transgene insertion

abnormal bone ossification ( J:179873 )

• mice exhibit impaired bone formation rate compared with non-transgenic mice and to a greater extent than in mice hemizygous for transgene insertion

limbs/digits/tail

abnormal phalanx morphology ( J:179873 )

• mice exhibit a wide range of fused and missing digits

fused phalanges ( J:179873 )

abnormal digit development ( J:179873 )

• mice exhibit a wide range of fused and missing digits

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
SOST-related sclerosing bone dysplasia		DOID:0080036	OMIM:239100	J:99965

Genotype
MGI:5304472

tg2

• Allelic Composition: Tg(RP11-209M4)AGglo/0
• Genetic Background: FVB-Tg(RP11-209M4)4Gglo

skeleton

skeleton phenotype ( J:99965 )

N • mice exhibit number numbers of osteocytes and osteoclasts

decreased bone mineral density ( J:99965 )

decreased bone volume ( J:99965 )

increased bone trabecula number ( J:99965 )

• with increased trabecular separation

decreased trabecular bone thickness ( J:99965 )

abnormal bone ossification ( J:99965 )

• mice exhibit impaired bone formation rate compared with non-transgenic mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
SOST-related sclerosing bone dysplasia		DOID:0080036	OMIM:239100	J:99965

Genotype
MGI:5304493

tg3

• Allelic Composition: Tg(RP11-209M4)AGglo/0
• Genetic Background: involves: C57BL/6 * FVB

skeleton

decreased bone mineral density ( J:179873 )

• with increasing age

decreased compact bone thickness ( J:179873 )

• in aging mice

abnormal bone ossification ( J:179873 )

• PTH-induced bone gain and bone formation rate are blunted compared to in similarly treated wild-type mice

• however, bone resorption in PTH-treated mice is normal

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:179873 )

• PTH-induced bone gain and bone formation rate are blunted compared to in similarly treated wild-type mice

• however, bone resorption in PTH-treated mice is normal