Phenotypes associated with this allele

• Allele Symbol: Sost^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:5304482
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sost^tm1Dgen/Sost^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:5304492

Genotype
MGI:5304492

hm1

• Allelic Composition: Sost^tm1Dgen/Sost^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased bone mineral density ( J:179873 )

• in untreated mice

• in the tibia and lumbar vertebrae, but not total skeleton, of PTH-treated mice

increased bone mineral density of lumbar vertebrae ( J:179873 )

• increased bone mineral density in lumbar vertebrae of PTH-treated mice

increased compact bone thickness ( J:179873 )

increased bone mass ( J:179873 )

abnormal bone ossification ( J:179873 )

• PTH-induced bone gain and bone formation rate are blunted compared to in similarly treated wild-type mice irrespective of PTH dose

• however, bone resorption in PTH-treated mice is normal

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:179873 )

• PTH-induced bone gain and bone formation rate are blunted compared to in similarly treated wild-type mice irrespective of PTH dose

• however, bone resorption in PTH-treated mice is normal