Phenotypes associated with this allele

• Allele Symbol: Thra^tm1.1Fcas
• Allele Name: targeted mutation 1.1, Francois Casas
• Allele ID: MGI:5304668
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thra^tm1.1Fcas/Thra^tm1.1Fcas	B6.Cg-Thra^tm1.1Fcas	MGI:5304673

Genotype
MGI:5304673

hm1

• Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas
• Genetic Background: B6.Cg-Thra^tm1.1Fcas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating thyroxine level ( J:179839 )

• total T4

increased circulating triiodothyronine level ( J:179839 )

• total and free T3

decreased body temperature ( J:179839 )

• moderate

abnormal glucose homeostasis ( J:179839 )

• whether fed standard chow or a high-fat and high-sucrose diet, mice re-fed after fasting fail to exhibit an increase in plasma insulin levels unlike wild-type mice

• mice fed glucose fail to exhibit an increase in plasma insulin levels unlike wild-type mice

increased glucagon secretion ( J:179839 )

• from islets under low or increased glucose conditions

abnormal insulin secretion ( J:179839 )

• islets fail to increase glucose secretion under increased glucose conditions

increased insulin secretion ( J:179839 )

• from islets under low glucose conditions

increased circulating glucose level ( J:179839 )

• in fed mice when fed a high-fat and high-sucrose diet

increased circulating glucagon level ( J:179839 )

• in fasted mice and after re-feeding

increased circulating insulin level ( J:179839 )

• in fasted mice, whether fed standard chow or a high-fat and high-sucrose diet

impaired glucose tolerance ( J:179839 )

• when fed a high-fat and high-sucrose diet

increased insulin sensitivity ( J:179839 )

• in mice fed standard chow but not in mice fed a high-fat and high-sucrose diet

insulin resistance ( J:179839 )

• when fed a high-fat and high-sucrose diet

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:179839 )

• decreased islet size and density

• however, the alpha and beta cell ratio is normal

small pancreatic islets ( J:179839 )

increased glucagon secretion ( J:179839 )

• from islets under low or increased glucose conditions

abnormal insulin secretion ( J:179839 )

• islets fail to increase glucose secretion under increased glucose conditions

increased insulin secretion ( J:179839 )

• from islets under low glucose conditions

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:179839 )

• islet cells exhibit reduced complex I and complex IV maximal activities compared with wild-type cells

behavior/neurological

decreased food intake ( J:179839 )

• when fed a high-fat and high-sucrose diet