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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1Uga
targeted mutation 1, Marcus Fechheimer
MGI:5304689
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1Uga/Gt(ROSA)26Sortm1Uga
Tg(Thy1-cre)703Vaw/0 		involves: C3H * C57BL/6 * C57BL/6J MGI:5304691


Genotype
MGI:5304691
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1Uga/Gt(ROSA)26Sortm1Uga
Tg(Thy1-cre)703Vaw/0
Genetic
Background		 involves: C3H * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Uga mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Thy1-cre)703Vaw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Hirano Bodies are seen in Gt(ROSA)26Sortm1Uga/Gt(ROSA)26Sortm1Uga Tg(Thy1-cre)703Vaw/0 mice

nervous system
abnormal neuron morphology ( J:179833 )
• at 6 months, mice exhibit Hirano bodies in the hippocampus
abnormal synaptic transmission ( J:179833 )
• mice exhibit paired-pulse depression instead of facilitation unlike in wild-type mice
reduced long-term potentiation ( J:179833 )
• early LTP, but not late LTP




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory