Phenotypes associated with this allele

• Allele Symbol: Igh-J^{tm1(CB20)Riho}
• Allele Name: targeted mutation 1, Rikard Holmdahl
• Allele ID: MGI:5304723
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh-J^tm1(CB20)Riho/Igh-J^tm1(CB20)Riho	involves: C57BL/10 * DBA/1	MGI:5304726
ht2	Igh-J^tm1(CB20)Riho/Igh-J^+	involves: C57BL/10 * DBA/1	MGI:5304727

Genotype
MGI:5304726

hm1

• Allelic Composition: Igh-J^{tm1(CB20)Riho}/Igh-J^{tm1(CB20)Riho}
• Genetic Background: involves: C57BL/10 * DBA/1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:179456 )

• proper-B cells are decreased in the bone marrow compared to in wild-type mice

increased immature B cell number ( J:179456 )

• in the bone marrow

increased mature B cell number ( J:179456 )

• in the bone marrow

increased marginal zone B cell number ( J:179456 )

decreased pre-B cell number ( J:179456 )

• in the bone marrow

increased susceptibility to induced arthritis ( J:179456 )

• following injection an antibody mixture containing CIIC2 (recognizing D3 epitope), M2139 (J1 epitope), and UL1 (U1 epitope), mice exhibit increased incidence and severity of arthritis compared with wild-type mice

skeleton

increased susceptibility to induced arthritis ( J:179456 )

• following injection an antibody mixture containing CIIC2 (recognizing D3 epitope), M2139 (J1 epitope), and UL1 (U1 epitope), mice exhibit increased incidence and severity of arthritis compared with wild-type mice

hematopoietic system

abnormal B cell differentiation ( J:179456 )

• proper-B cells are decreased in the bone marrow compared to in wild-type mice

increased immature B cell number ( J:179456 )

• in the bone marrow

increased mature B cell number ( J:179456 )

• in the bone marrow

increased marginal zone B cell number ( J:179456 )

decreased pre-B cell number ( J:179456 )

• in the bone marrow

Genotype
MGI:5304727

ht2

• Allelic Composition: Igh-J^{tm1(CB20)Riho}/Igh-J⁺
• Genetic Background: involves: C57BL/10 * DBA/1

immune system

abnormal B cell differentiation ( J:179456 )

• proper-B cells are decreased in the bone marrow compared to in wild-type mice

increased immature B cell number ( J:179456 )

• in the bone marrow

increased mature B cell number ( J:179456 )

• in the bone marrow

increased marginal zone B cell number ( J:179456 )

decreased pre-B cell number ( J:179456 )

• in the bone marrow

increased susceptibility to induced arthritis ( J:179456 )

• following injection an antibody mixture containing CIIC2 (recognizing D3 epitope), M2139 (J1 epitope), and UL1 (U1 epitope), mice exhibit increased incidence and severity of arthritis compared with wild-type mice

skeleton

increased susceptibility to induced arthritis ( J:179456 )

• following injection an antibody mixture containing CIIC2 (recognizing D3 epitope), M2139 (J1 epitope), and UL1 (U1 epitope), mice exhibit increased incidence and severity of arthritis compared with wild-type mice

hematopoietic system

abnormal B cell differentiation ( J:179456 )

• proper-B cells are decreased in the bone marrow compared to in wild-type mice

increased immature B cell number ( J:179456 )

• in the bone marrow

increased mature B cell number ( J:179456 )

• in the bone marrow

increased marginal zone B cell number ( J:179456 )

decreased pre-B cell number ( J:179456 )

• in the bone marrow