All Phenotypes Col1a1<tm2(tetO-RNAi:Rps19)Karl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Col1a1^{tm2(tetO-RNAi:Rps19)Karl}
targeted mutation 2, Stefan Karlsson
MGI:5304755

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Col1a1^{tm2(tetO-RNAi:Rps19)Karl}/Col1a1^{tm2(tetO-RNAi:Rps19)Karl} Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}	involves: 129S4/SvJae * C57BL/6	MGI:5304758
cx2	Col1a1^{tm2(tetO-RNAi:Rps19)Karl}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}	involves: 129S4/SvJae * C57BL/6	MGI:5304759

Allelic Composition	Col1a1^{tm2(tetO-RNAi:Rps19)Karl}/Col1a1^{tm2(tetO-RNAi:Rps19)Karl} Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm2(tetO-RNAi:Rps19)Karl} mutation (1 available); any Col1a1 mutation (161 available)
Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} mutation (30 available); any Gt(ROSA)26Sor mutation (985 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179085 )

• most mice die within 2 months following doxycycline treatment

hematopoietic system

macrocytosis ( J:179085 )

• seven weeks after doxycycline treatment

thrombocytosis ( J:179085 )

• two weeks after doxycycline treatment

decreased hematopoietic cell number ( J:179085 )

decreased erythrocyte cell number ( J:179085 )

• two and seven weeks after doxycycline treatment

decreased neutrophil cell number ( J:179085 )

• seven weeks after doxycycline treatment

thrombocytopenia ( J:179085 )

• seven weeks after doxycycline treatment

decreased lymphocyte cell number ( J:179085 )

• two and seven weeks after doxycycline treatment

reticulocytopenia ( J:179085 )

• two weeks after doxycycline treatment

growth/size/body

postnatal growth retardation ( J:179085 )

• following doxycycline treatment

immune system

decreased neutrophil cell number ( J:179085 )

• seven weeks after doxycycline treatment

decreased lymphocyte cell number ( J:179085 )

• two and seven weeks after doxycycline treatment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Diamond-Blackfan anemia		DOID:1339	OMIM:PS105650	J:179085

Allelic Composition	Col1a1^{tm2(tetO-RNAi:Rps19)Karl}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:179085 )

N	• unlike homozygous mice, heterozygotes survive at least 3 months following doxycycline treatment

hematopoietic system

macrocytosis ( J:179085 )

• seven weeks after doxycycline treatment

thrombocytosis ( J:179085 )

• two weeks after doxycycline treatment

decreased hematopoietic cell number ( J:179085 )

decreased erythrocyte cell number ( J:179085 )

• two and seven weeks after doxycycline treatment

thrombocytopenia ( J:179085 )

• seven weeks after doxycycline treatment

decreased lymphocyte cell number ( J:179085 )

• two and seven weeks after doxycycline treatment

reticulocytopenia ( J:179085 )

• two weeks after doxycycline treatment

growth/size/body

postnatal growth retardation ( J:179085 )

• following doxycycline treatment

• less pronounced than in homozygous mice

immune system

decreased lymphocyte cell number ( J:179085 )

• two and seven weeks after doxycycline treatment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Diamond-Blackfan anemia		DOID:1339	OMIM:PS105650	J:179085

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