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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Prnp-HTT*82Q)52Caro
transgene insertion 52, Christopher A Ross
MGI:5304797
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Prnp-HTT*82Q)52Caro/0 involves: C3H * C57BL/6 MGI:5304801


Genotype
MGI:5304801
tg1
Allelic
Composition
Tg(Prnp-HTT*82Q)52Caro/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants die around 1 year of age

growth/size/body
• signs of deterioration become apparent in males at 6 months of age
• weight loss begins at around 4 months of age and continues progressively with disease

behavior/neurological
• at 8 months of age, mutants exhibit signs of cognitive impairment in the fear conditioning paradigm
• on the second day of a fear conditioning paradigm, mutants exhibit a reduction in the amount of time spent freezing compared to controls, indicating impaired contextual memory
• on the third day of a fear conditioning paradigm, mutants show an even larger deficit in cue-dependent memory
• mutants exhibit frequent clasping when suspended by tail
• mutants exhibit impaired rotarod performance beginning at 4 months of age
• toward end stage of disease, mutants have a hunched posture
• toward end stage of disease, mutants become hypoactive and are immobile
• mutants become hyperactive after 5 months of age, which is even more pronounced at 7 months of age

nervous system
• at 8 months of age, mutants exhibit a 15.35% decrease in whole brain size indicating brain atrophy

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:179364





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory