Phenotypes associated with this allele

• Allele Symbol: Slc14a2^tm1Bxy
• Allele Name: targeted mutation 1, Baoxue Yang
• Allele ID: MGI:5304854
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Slc14a1^tm1Ask/Slc14a1^tm1Ask Slc14a2^tm1Bxy/Slc14a2^tm1Bxy	involves: C57BL/6J	MGI:5304901

Genotype
MGI:5304901

cx1

• Allelic Composition: Slc14a1^tm1Ask/Slc14a1^tm1Ask; Slc14a2^tm1Bxy/Slc14a2^tm1Bxy
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:179936 )

N • creatinine plasma levels and clearance are normal

decreased urine creatinine level ( J:179936 )

• not as severe as in Slc14a1^tm1Ask homozygotes

increased blood urea nitrogen level ( J:179936 )

• not as severe as in Slc14a1^tm1Ask homozygotes

decreased urine osmolality ( J:179936 )

• not as severe as in Slc14a1^tm1Ask homozygotes

• however, mice fed a high-protein diet exhibit normal increase in urine osmolality

renal/urinary system

decreased urine creatinine level ( J:179936 )

• not as severe as in Slc14a1^tm1Ask homozygotes

decreased urine osmolality ( J:179936 )

• not as severe as in Slc14a1^tm1Ask homozygotes

• however, mice fed a high-protein diet exhibit normal increase in urine osmolality

abnormal renal filtration rate ( J:179936 )

• urea clearance is reduced compared to in wild-type mice but not as severely as in Slc14a1^tm1Ask homozygotes

• following acute urea loading, early phase concentration of urine urea is increased compared to in Slc14a1^tm1Ask homozygotes as in wild-type mice while late phase concentration of urea in the urine fails to occur as in wild-type mice

polyuria ( J:179936 )

• not as severe as in Slc14a1^tm1Ask homozygotes

behavior/neurological

increased fluid intake ( J:179936 )

• not as severe as in Slc14a1^tm1Ask homozygotes