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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		P2ry6tm1Jabo
targeted mutation 1, Joshua A Boyce
MGI:5304911
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		P2ry6tm1Jabo/P2ry6tm1Jabo
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo MGI:5304918
cn2
 		P2ry6tm1Jabo/P2ry6tm1Jabo
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: 129 * C57BL/6 * C57BL/6NTac MGI:5304917


Genotype
MGI:5304918
cn1
Allelic
Composition		 P2ry6tm1Jabo/P2ry6tm1Jabo
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (997 available)
P2ry6tm1Jabo mutation (1 available); any P2ry6 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased eosinophil cell number ( J:179177 )
• in the bronchioalveolar following exposure to Dermatophagoides farinae in tamoxifen-treated mice
increased neutrophil cell number ( J:179177 )
• in the bronchioalveolar following exposure to Dermatophagoides farinae in tamoxifen-treated mice
increased interferon-gamma secretion ( J:179177 )
• in restimulated cells from the parabronchial lymph node or splenocytes of tamoxifen-treated Dermatophagoides farinae-exposed mice
increased interleukin-13 secretion ( J:179177 )
• in restimulated cells from the parabronchial lymph node or splenocytes of tamoxifen-treated Dermatophagoides farinae-exposed mice
increased interleukin-5 secretion ( J:179177 )
• in restimulated cells from the parabronchial lymph node or splenocytes of tamoxifen-treated Dermatophagoides farinae-exposed mice
lung inflammation ( J:179177 )
• following exposure to Dermatophagoides farinae, tamoxifen-treated mice exhibit increased total cells in the bronchioalveolar fluid (5-fold increase in eosinophils and neutrophils), increased goblet cell metaplasia, and increased cytokine secretion (IL4, IL5, IL13, and IFN-gamma) compared with control mice

respiratory system
lung inflammation ( J:179177 )
• following exposure to Dermatophagoides farinae, tamoxifen-treated mice exhibit increased total cells in the bronchioalveolar fluid (5-fold increase in eosinophils and neutrophils), increased goblet cell metaplasia, and increased cytokine secretion (IL4, IL5, IL13, and IFN-gamma) compared with control mice
abnormal respiratory mucosa goblet cell morphology ( J:179177 )
• following exposure to Dermatophagoides farinae in tamoxifen-treated mice

hematopoietic system
increased eosinophil cell number ( J:179177 )
• in the bronchioalveolar following exposure to Dermatophagoides farinae in tamoxifen-treated mice
increased neutrophil cell number ( J:179177 )
• in the bronchioalveolar following exposure to Dermatophagoides farinae in tamoxifen-treated mice




Genotype
MGI:5304917
cn2
Allelic
Composition		 P2ry6tm1Jabo/P2ry6tm1Jabo
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (997 available)
P2ry6tm1Jabo mutation (1 available); any P2ry6 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell apoptosis ( J:179177 )
• the percentage of polyclonally stimulated apoptotic CD4+ T cells of the parabronchial lymph node from tamoxifen-treated is decreased compared to in control mice
increased T cell proliferation ( J:179177 )
• the percentage of polyclonally stimulated proliferating CD4+ T cells of the parabronchial lymph node or spleen from tamoxifen-treated is increased compared to in control mice
increased eosinophil cell number ( J:179177 )
• in the bronchioalveolar following exposure to Dermatophagoides farinae in tamoxifen-treated mice
increased neutrophil cell number ( J:179177 )
• in the bronchioalveolar following exposure to Dermatophagoides farinae in tamoxifen-treated mice
decreased IgE level ( J:179177 )
• following exposure to Dermatophagoides farinae in tamoxifen-treated mice

immune system
decreased T cell apoptosis ( J:179177 )
• the percentage of polyclonally stimulated apoptotic CD4+ T cells of the parabronchial lymph node from tamoxifen-treated is decreased compared to in control mice
increased T cell proliferation ( J:179177 )
• the percentage of polyclonally stimulated proliferating CD4+ T cells of the parabronchial lymph node or spleen from tamoxifen-treated is increased compared to in control mice
increased eosinophil cell number ( J:179177 )
• in the bronchioalveolar following exposure to Dermatophagoides farinae in tamoxifen-treated mice
increased neutrophil cell number ( J:179177 )
• in the bronchioalveolar following exposure to Dermatophagoides farinae in tamoxifen-treated mice
decreased IgE level ( J:179177 )
• following exposure to Dermatophagoides farinae in tamoxifen-treated mice
increased interferon-gamma secretion ( J:179177 )
• in restimulated cells from the parabronchial lymph node or splenocytes of tamoxifen-treated Dermatophagoides farinae-exposed mice
• in CD3+/CD4+ T cells from tamoxifen-treated Dermatophagoides farinae-exposed mice
increased interleukin-13 secretion ( J:179177 )
• in restimulated cells from the parabronchial lymph node or splenocytes of tamoxifen-treated Dermatophagoides farinae-exposed mice
• in CD3+/CD4+ T cells from tamoxifen-treated Dermatophagoides farinae-exposed mice
increased interleukin-5 secretion ( J:179177 )
• in restimulated cells from the parabronchial lymph node or splenocytes of tamoxifen-treated Dermatophagoides farinae-exposed mice
• in CD3+/CD4+ T cells from tamoxifen-treated Dermatophagoides farinae-exposed mice
lung inflammation ( J:179177 )
• following exposure to Dermatophagoides farinae, tamoxifen-treated mice exhibit increased total cells in the bronchioalveolar fluid (5-fold increase in eosinophils and neutrophils), increased goblet cell metaplasia, and increased cytokine secretion (IL4, IL5, IL13, and IFN-gamma) compared with control mice

respiratory system
lung inflammation ( J:179177 )
• following exposure to Dermatophagoides farinae, tamoxifen-treated mice exhibit increased total cells in the bronchioalveolar fluid (5-fold increase in eosinophils and neutrophils), increased goblet cell metaplasia, and increased cytokine secretion (IL4, IL5, IL13, and IFN-gamma) compared with control mice
abnormal respiratory mucosa goblet cell morphology ( J:179177 )
• following exposure to Dermatophagoides farinae in tamoxifen-treated mice

cellular
decreased T cell apoptosis ( J:179177 )
• the percentage of polyclonally stimulated apoptotic CD4+ T cells of the parabronchial lymph node from tamoxifen-treated is decreased compared to in control mice
increased T cell proliferation ( J:179177 )
• the percentage of polyclonally stimulated proliferating CD4+ T cells of the parabronchial lymph node or spleen from tamoxifen-treated is increased compared to in control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory