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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc34a2tm1Sega
targeted mutation 1, Hiroko Segawa
MGI:5305039
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc34a2tm1Sega/Slc34a2tm1Sega involves: 129S6/SvEvTac * C57BL/6JJcl MGI:5305042
ht2
 		Slc34a2tm1Sega/Slc34a2+ involves: 129S6/SvEvTac * C57BL/6JJcl MGI:5305043


Genotype
MGI:5305042
hm1
Allelic
Composition		 Slc34a2tm1Sega/Slc34a2tm1Sega
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc34a2tm1Sega mutation (0 available); any Slc34a2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo




Genotype
MGI:5305043
ht2
Allelic
Composition		 Slc34a2tm1Sega/Slc34a2+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc34a2tm1Sega mutation (0 available); any Slc34a2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating creatinine level ( J:179947 )
• in an adenine-induced renal failure model
decreased circulating calcium level ( J:179947 )
• at 4, but not 20, weeks of age
decreased circulating phosphate level ( J:179947 )
• at 4, but not 20, weeks of age
• in an adenine-induced renal failure model
increased urine calcium level ( J:179947 )
• at 4, but not 20, weeks of age
abnormal vitamin D level ( J:179947 )
• increased in the plasma at 4 weeks of age
decreased urine phosphate level ( J:179947 )
• at 4 and 20 weeks of age
decreased susceptibility to injury ( J:179947 )
• in an adenine-induced renal failure model, mice exhibit decreased plasma creatinine, phosphate, and calcium compared with wild-type mice

digestive/alimentary system
abnormal intestine physiology ( J:179947 )
• at 4 and 20 weeks of age, sodium-dependent phosphate transport activity is decreased in the distal intestine compared to in wild-type mice
• however, uptake in the proximal intestine is normal

renal/urinary system
increased urine calcium level ( J:179947 )
• at 4, but not 20, weeks of age
decreased urine phosphate level ( J:179947 )
• at 4 and 20 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory