Phenotypes associated with this allele

• Allele Symbol: Gak^tm1Noj
• Allele Name: targeted mutation 1, Hiroshi Nojima
• Allele ID: MGI:5305045
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gak^tm1Noj/Gak^tm1Noj	C57BL/6-Gak^tm1Noj	MGI:5305046

Genotype
MGI:5305046

hm1

• Allelic Composition: Gak^tm1Noj/Gak^tm1Noj
• Genetic Background: C57BL/6-Gak^tm1Noj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lung tissue defects in Gak^tm1Noj/Gak^tm1Noj pups

mortality/aging

neonatal lethality, complete penetrance ( J:179585 )

• all pups die shortly after birth

respiratory system

abnormal lung alveolus development ( J:179585 )

• expression analysis indicates a defect in alveolar cell maturation

abnormal pulmonary alveolar sac morphology ( J:179585 )

• at E19.5 lungs are more elaborately compartmentalized into smaller alveolar lumens and display a significant increase in the total number of alveolar compartments and decrease in the total area of alveolar compartments

abnormal pulmonary interalveolar septum morphology ( J:179585 )

• thinner at E19.5

abnormal surfactant physiology ( J:179585 )

• abnormal distribution of surfactant protein A

cellular

cellular phenotype ( J:179585 )

N • membrane trafficking and autophagy are normal in MEFs