About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr7tm3.1Kio
targeted mutation 3.1, Dimitris Kioussis
MGI:5305062
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Rr7tm3.1Kio/Rr7+ B6.129S4-Rr7tm3.1Kio MGI:5305072
cn2
 		Rr7tm3.1Kio/Rr7+
Tg(CD2-icre)4Kio/0 		involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca MGI:5305075
cn3
 		Rr7tm3.1Kio/Rr7+
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca MGI:5305077
cn4
 		Rr7tm3.1Kio/Rr7+
Tg(Lck-cre)#Nik/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:5305076


Genotype
MGI:5305072
ht1
Allelic
Composition		 Rr7tm3.1Kio/Rr7+
Genetic
Background		 B6.129S4-Rr7tm3.1Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive, alpha beta T cell morphology ( J:179326 )
• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8
• however, the number of CD4+(CD8+) decreases with age due to thymus involution

immune system
abnormal CD4-positive, alpha beta T cell morphology ( J:179326 )
• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8
• however, the number of CD4+(CD8+) decreases with age due to thymus involution




Genotype
MGI:5305075
cn2
Allelic
Composition		 Rr7tm3.1Kio/Rr7+
Tg(CD2-icre)4Kio/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr7tm3.1Kio mutation (0 available); any Rr7 mutation (0 available)
Tg(CD2-icre)4Kio mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:179326 )
N
• mice exhibit normal expression of Cd8a and Cd8b




Genotype
MGI:5305077
cn3
Allelic
Composition		 Rr7tm3.1Kio/Rr7+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Rr7tm3.1Kio mutation (0 available); any Rr7 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:179326 )
N
• mice exhibit normal expression of Cd8a and Cd8b




Genotype
MGI:5305076
cn4
Allelic
Composition		 Rr7tm3.1Kio/Rr7+
Tg(Lck-cre)#Nik/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive, alpha beta T cell morphology ( J:179326 )
• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8
• however, the number of CD4+(CD8+) decreases with age compared with Rr7tm3.1Kio heterozygotes due to cre-mediated removal of the CD2 LCR

immune system
abnormal CD4-positive, alpha beta T cell morphology ( J:179326 )
• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8
• however, the number of CD4+(CD8+) decreases with age compared with Rr7tm3.1Kio heterozygotes due to cre-mediated removal of the CD2 LCR




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory