Analysis Tools
mortality/aging
reproductive system
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• total numbers and the number in the gonads are decreased at E11.5 and E12.5, but not at E10.5
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• cultured primordial germ cells show impaired elongation and alignment along an SCF (secreted Kit ligand) gradient
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• increase in apoptosis of extragonadal primordial germ cells at E10.5 and E11.5
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• ectopic PGCs are seen in the allantois, throughout the tail mesoderm, and caudal hindgut at E9.0
• fail to migrate rostrally at E10.5, remaining in the mesentery surrounding the caudal hindgut as well as on the surface of the tail and in the allantois
• at E11.5 the distribution of PGCs is skewed toward the caudal end of the gonad and an increased number of extragonadal PGCs are present in midline tissues
• ectopic PGCs make up 30% of the total PGCs at E11.5 compared to less than 5% in wild-type controls
• cell elongation of migratory PGCs is impaired at E9.75-E10.75
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digestive/alimentary system
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• wider and shorter caudal hindgut at E9.5
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limbs/digits/tail
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• defects in tail elongation
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embryo
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• defects in somite segmentation
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cellular
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• total numbers and the number in the gonads are decreased at E11.5 and E12.5, but not at E10.5
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• increase in apoptosis of extragonadal primordial germ cells at E10.5 and E11.5
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• ectopic PGCs are seen in the allantois, throughout the tail mesoderm, and caudal hindgut at E9.0
• fail to migrate rostrally at E10.5, remaining in the mesentery surrounding the caudal hindgut as well as on the surface of the tail and in the allantois
• at E11.5 the distribution of PGCs is skewed toward the caudal end of the gonad and an increased number of extragonadal PGCs are present in midline tissues
• ectopic PGCs make up 30% of the total PGCs at E11.5 compared to less than 5% in wild-type controls
• cell elongation of migratory PGCs is impaired at E9.75-E10.75
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