Phenotypes associated with this allele

• Allele Symbol: Cdh5^{tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst}
• Allele Name: targeted mutation 4, Dietmar Vestweber
• Allele ID: MGI:5305106
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdh5^tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst/Cdh5^tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst	involves: C57BL/6	MGI:5305107

Genotype
MGI:5305107

hm1

• Allelic Composition: Cdh5^{tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst}/Cdh5^{tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased vascular permeability ( J:178759 )

• after treatment with rapalog the induction of vascular permeability by VEGF severely inhibited

• in the absence of rapalog no defect in the induction of vascular permeability by VEGF is detected

immune system

abnormal cellular extravasation ( J:178759 )

• after treatment with rapalog IL1B induced extravasion of leukocytes is reduced by about 50% compared to untreated mice

impaired neutrophil recruitment ( J:178759 )

• treatment with rapalog impairs neutrophil recruitment following LPS induced acute lung injury

cellular

abnormal cellular extravasation ( J:178759 )

• after treatment with rapalog IL1B induced extravasion of leukocytes is reduced by about 50% compared to untreated mice

hematopoietic system

abnormal cellular extravasation ( J:178759 )

• after treatment with rapalog IL1B induced extravasion of leukocytes is reduced by about 50% compared to untreated mice

impaired neutrophil recruitment ( J:178759 )

• treatment with rapalog impairs neutrophil recruitment following LPS induced acute lung injury