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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pbx1tm1Koss
targeted mutation 1, Matthew J Koss
MGI:5305253
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pbx1tm1Koss/Pbx1tm1Koss
Pbx3tm1Mlc/Pbx3+
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd MGI:5305924
cn2
 		Pbx1tm1Koss/Pbx1tm1Koss
Pbx3tm1Mlc/Pbx3+
Tg(Tcfap2a-cre)1Will/0 		involves: 129P2/OlaHsd MGI:5305926
cn3
 		Pbx1tm1Koss/Pbx1tm1Koss
Nkx2-5tm2(cre)Rph/Nkx2-5+ 		involves: 129P2/OlaHsd * 129S1/Sv MGI:5426980
cn4
 		Cdkn2btm1Bbd/Cdkn2btm1Bbd
Pbx1tm1Koss/Pbx1tm1Koss
Nkx2-5tm2(cre)Rph/Nkx2-5+ 		involves: 129P2/OlaHsd * 129S1/Sv MGI:5426986
cn5
 		Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2tm1Mlc
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * 129S/Sv MGI:5305923
cn6
 		Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * 129S/Sv MGI:5305855
cn7
 		Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Tg(Tcfap2a-cre)1Will/0 		involves: 129P2/OlaHsd * 129S/Sv MGI:5305925
cn8
 		Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Nkx2-5tm2(cre)Rph/Nkx2-5+ 		involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv MGI:5426982
cn9
 		Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Tg(Tcfap2a-cre)1Will/0 		involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ MGI:5305934
cn10
 		Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA/J MGI:5305927


Genotype
MGI:5305924
cn1
Allelic
Composition		 Pbx1tm1Koss/Pbx1tm1Koss
Pbx3tm1Mlc/Pbx3+
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx3tm1Mlc mutation (0 available); any Pbx3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft upper lip ( J:178316 )
• cleft lip and/or palate
cleft palate ( J:178316 )
• cleft lip and/or palate

digestive/alimentary system
cleft palate ( J:178316 )
• cleft lip and/or palate

growth/size/body
cleft upper lip ( J:178316 )
• cleft lip and/or palate
cleft palate ( J:178316 )
• cleft lip and/or palate




Genotype
MGI:5305926
cn2
Allelic
Composition		 Pbx1tm1Koss/Pbx1tm1Koss
Pbx3tm1Mlc/Pbx3+
Tg(Tcfap2a-cre)1Will/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx3tm1Mlc mutation (0 available); any Pbx3 mutation (35 available)
Tg(Tcfap2a-cre)1Will mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft upper lip ( J:178316 )
• cleft lip and/or palate
cleft palate ( J:178316 )
• cleft lip and/or palate

digestive/alimentary system
cleft palate ( J:178316 )
• cleft lip and/or palate

growth/size/body
cleft upper lip ( J:178316 )
• cleft lip and/or palate
cleft palate ( J:178316 )
• cleft lip and/or palate




Genotype
MGI:5426980
cn3
Allelic
Composition		 Pbx1tm1Koss/Pbx1tm1Koss
Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm2(cre)Rph mutation (1 available); any Nkx2-5 mutation (21 available)
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal spleen morphology ( J:184521 )
• hypoplastic and fragmented
abnormal spleen mesenchyme morphology ( J:184521 )
• significant decrease of mitotic mesenchymal cells in the anlagen

immune system
abnormal spleen morphology ( J:184521 )
• hypoplastic and fragmented
abnormal spleen mesenchyme morphology ( J:184521 )
• significant decrease of mitotic mesenchymal cells in the anlagen




Genotype
MGI:5426986
cn4
Allelic
Composition		 Cdkn2btm1Bbd/Cdkn2btm1Bbd
Pbx1tm1Koss/Pbx1tm1Koss
Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2btm1Bbd mutation (1 available); any Cdkn2b mutation (7 available)
Nkx2-5tm2(cre)Rph mutation (1 available); any Nkx2-5 mutation (21 available)
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal spleen morphology ( J:184521 )
• partial rescue of spleen expansion compared to mutant mice wild-type for Cdkn2b and spleens form a single compact anlage
abnormal spleen mesenchyme morphology ( J:184521 )
• significant rescue of mesenchymal proliferation compared to mutant mice wild-type for Cdkn2b

immune system
abnormal spleen morphology ( J:184521 )
• partial rescue of spleen expansion compared to mutant mice wild-type for Cdkn2b and spleens form a single compact anlage
abnormal spleen mesenchyme morphology ( J:184521 )
• significant rescue of mesenchymal proliferation compared to mutant mice wild-type for Cdkn2b




Genotype
MGI:5305923
cn5
Allelic
Composition		 Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2tm1Mlc
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
bilateral cleft upper lip ( J:178316 )
• bilateral cleft lip

cellular
decreased apoptosis ( J:178316 )
• in the nasal epithelial at E10.75

growth/size/body
bilateral cleft upper lip ( J:178316 )
• bilateral cleft lip




Genotype
MGI:5305855
cn6
Allelic
Composition		 Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
abnormal maxillary shelf morphology ( J:178316 )
• abnormal maxillary palatal and palatine process
absent premaxilla ( J:178316 )
• the premaxillary process is absent
bilateral cleft upper lip ( J:178316 )
• bilateral cleft lip

respiratory system

digestive/alimentary system
abnormal maxillary shelf morphology ( J:178316 )
• abnormal maxillary palatal and palatine process

skeleton
abnormal maxillary shelf morphology ( J:178316 )
• abnormal maxillary palatal and palatine process
absent premaxilla ( J:178316 )
• the premaxillary process is absent

growth/size/body
abnormal maxillary shelf morphology ( J:178316 )
• abnormal maxillary palatal and palatine process
abnormal nasal capsule morphology ( J:178316 )
bilateral cleft upper lip ( J:178316 )
• bilateral cleft lip
cleft palate ( J:178316 )




Genotype
MGI:5305925
cn7
Allelic
Composition		 Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Tg(Tcfap2a-cre)1Will/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
Tg(Tcfap2a-cre)1Will mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft upper lip ( J:178316 )
• cleft lip and/or palate
cleft palate ( J:178316 )
• cleft lip and/or palate

digestive/alimentary system
cleft palate ( J:178316 )
• cleft lip and/or palate

growth/size/body
cleft upper lip ( J:178316 )
• cleft lip and/or palate
cleft palate ( J:178316 )
• cleft lip and/or palate




Genotype
MGI:5426982
cn8
Allelic
Composition		 Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm2(cre)Rph mutation (1 available); any Nkx2-5 mutation (21 available)
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal spleen morphology ( J:184521 )
• hypoplastic and fragmented
• more severe than in mutant mice wild-type for Pbx2

immune system
abnormal spleen morphology ( J:184521 )
• hypoplastic and fragmented
• more severe than in mutant mice wild-type for Pbx2




Genotype
MGI:5305934
cn9
Allelic
Composition		 Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Tg(Tcfap2a-cre)1Will/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Wnt1/GFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
Tg(Tcfap2a-cre)1Will mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:178316 )
N
• the cleft lip phenotype observed in Pbx1tm1.1Koss/Pbx1tm1.1Koss Pbx2tm1Mlc/Pbx2+ Tg(Tcfap2a*-cre)1Will is rescued




Genotype
MGI:5305927
cn10
Allelic
Composition		 Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

craniofacial

nervous system
nervous system phenotype ( J:178316 )
N
• cranial neural crest cell migration and olfactory placodes are normal

digestive/alimentary system

growth/size/body
cleft palate ( J:178316 )




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory