Phenotypes associated with this allele

• Allele Symbol: Irak1^tm1.1Pcoh
• Allele Name: targeted mutation 1.1, Philip Cohen
• Allele ID: MGI:5305277
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irak1^tm1.1Pcoh/Irak1^tm1.1Pcoh	involves: 129P2/OlaHsd * C57BL/6	MGI:5305283
cx2	Irak1^tm1.1Pcoh/? Irak2^tm1.1Pcoh/?	involves: 129P2/OlaHsd * C57BL/6	MGI:5548134
ot3	Irak1^tm1.1Pcoh/Y	involves: 129P2/OlaHsd * C57BL/6	MGI:5305284
ot4	Irak1^tm1.1Pcoh/?	involves: 129P2/OlaHsd	MGI:5548132

Genotype
MGI:5305283

hm1

• Allelic Composition: Irak1^tm1.1Pcoh/Irak1^tm1.1Pcoh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:179219 )

♀ • mice are born at normal Mendelian frequencies, are of normal size and weight, and did not spontaneously develop any obvious phenotype

Genotype
MGI:5548134

cx2

• Allelic Composition: Irak1^tm1.1Pcoh/?; Irak2^tm1.1Pcoh/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

decreased interferon-alpha secretion ( J:205798 )

• from plasmacytoid dendritic cell stimulated with CpG-B, CpG-A or the TLR7 agonist poly(dU)

Genotype
MGI:5305284

ot3

• Allelic Composition: Irak1^tm1.1Pcoh/Y
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:179219 )

♂ • mice are born at normal Mendelian frequencies, are of normal size and weight, and did not spontaneously develop any obvious phenotype

Genotype
MGI:5548132

ot4

• Allelic Composition: Irak1^tm1.1Pcoh/?
• Genetic Background: involves: 129P2/OlaHsd

immune system

immune system phenotype ( J:205798 )

N • bone marrow-derived macrophage exhibit normal cytokine production

decreased interferon-alpha secretion ( J:205798 )

• from plasmacytoid dendritic cell stimulated with CpG-A or the TLR7 agonist poly(dU)