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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sftpctm1(cre/ERT2)Blh
targeted mutation 1, Brigid L Hogan
MGI:5305340
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Krastm4Tyj/Kras+
Sftpctm1(cre/ERT2)Blh/Sftpc+
Trp53tm5Tyj/Trp53+ 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 MGI:5317171
cn2
 		Ptpratm1c(EUCOMM)Hmgu/Ptpratm1c(EUCOMM)Hmgu
Sftpctm1(cre/ERT2)Blh/Sftpc+ 		involves: 129S6/SvEvTac * C57BL/6N MGI:6690444


Genotype
MGI:5317171
cn1
Allelic
Composition		 Krastm4Tyj/Kras+
Sftpctm1(cre/ERT2)Blh/Sftpc+
Trp53tm5Tyj/Trp53+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (12 available); any Kras mutation (87 available)
Sftpctm1(cre/ERT2)Blh mutation (1 available); any Sftpc mutation (24 available)
Trp53tm5Tyj mutation (1 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:182218 )
• mice die 14 weeks or less after tamoxifen administration

neoplasm
increased lung adenoma incidence ( J:182218 )
• at 6-8 weeks of age, animals administered 1dose or 4 doses of tamoxifen develop widespread adenomas in the alveoli by 14 weeks of age, but the bronchoalveolar duct junction remains tumor-free
increased adenocarcinoma incidence ( J:182218 )
• at 6-8 weeks of age, animals administered 1dose or 4 doses of tamoxifen develop widespread adenocarcinomas in the alveoli by 14 weeks of age

respiratory system
increased lung adenoma incidence ( J:182218 )
• at 6-8 weeks of age, animals administered 1dose or 4 doses of tamoxifen develop widespread adenomas in the alveoli by 14 weeks of age, but the bronchoalveolar duct junction remains tumor-free
abnormal pulmonary alveolus morphology ( J:182218 )
• at 2 weeks after tamoxifen treatement, brochioalveolar duct junctions (BADJ) appear normal, but small adenomas occur in the alveoli; these progress to adenocarcinoma but the BADJ remain histologically normal




Genotype
MGI:6690444
cn2
Allelic
Composition		 Ptpratm1c(EUCOMM)Hmgu/Ptpratm1c(EUCOMM)Hmgu
Sftpctm1(cre/ERT2)Blh/Sftpc+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpratm1c(EUCOMM)Hmgu mutation (0 available); any Ptpra mutation (45 available)
Sftpctm1(cre/ERT2)Blh mutation (1 available); any Sftpc mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:300194 )
N
• bleomycin, tamoxifen-treated mice develop fibrosis and lung collagen content as in control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory