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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam10tm1.1Khr
targeted mutation 1.1, Keisuke Horiuchi
MGI:5305451
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adam10tm1.1Khr/Adam10tm1.1Khr involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N MGI:5305471
cn2
 		Adam10tm1.1Khr/Adam10tm1.1Khr
Csf3rtm1Link/Csf3rtm1Link
Tg(Mx1-cre)1Cgn/0 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6N MGI:5305469
cn3
 		Adam10tm1.1Khr/Adam10tm1.1Khr
Tg(Mx1-cre)1Cgn/0 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N MGI:5305470


Genotype
MGI:5305471
hm1
Allelic
Composition		 Adam10tm1.1Khr/Adam10tm1.1Khr
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm1.1Khr mutation (0 available); any Adam10 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:179060 )
• mice are viable and fertile with no apparent defects




Genotype
MGI:5305469
cn2
Allelic
Composition		 Adam10tm1.1Khr/Adam10tm1.1Khr
Csf3rtm1Link/Csf3rtm1Link
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm1.1Khr mutation (0 available); any Adam10 mutation (38 available)
Csf3rtm1Link mutation (1 available); any Csf3r mutation (42 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal granulocyte differentiation ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
enlarged spleen ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
spleen hyperplasia ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
myeloid hyperplasia ( J:179060 )
• pIpC-treated mice exhibit an increase in Gr1+CD11b+ myeloid cells in the spleen compared with Csf3rtm1Link homozygotes

cellular
abnormal granulocyte differentiation ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r

immune system
abnormal granulocyte differentiation ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
enlarged spleen ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
spleen hyperplasia ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
myeloid hyperplasia ( J:179060 )
• pIpC-treated mice exhibit an increase in Gr1+CD11b+ myeloid cells in the spleen compared with Csf3rtm1Link homozygotes

growth/size/body
enlarged spleen ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
spleen hyperplasia ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r




Genotype
MGI:5305470
cn3
Allelic
Composition		 Adam10tm1.1Khr/Adam10tm1.1Khr
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm1.1Khr mutation (0 available); any Adam10 mutation (38 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
small thymus ( J:179060 )
• in pIpC-treated mice
thymus hypoplasia ( J:179060 )
• in pIpC-treated mice
abnormal definitive hematopoiesis ( J:179060 )
• splenocytes and bone marrow cells from pIpC-treated mice exhibit increased colony-forming units compared with control mice
abnormal granulocyte differentiation ( J:179060 )
• non-cell-autonomous in pIpC-treated mice
abnormal T cell differentiation ( J:179060 )
• at an early stage in pIpC-treated mice
myeloid hyperplasia ( J:179060 )
• pIpC-treated mice exhibit an increase in Gr1+CD11b+ myeloid cells in the spleen compared with control mice
• however, no difference was observed in the bone marrow
decreased erythrocyte cell number ( J:179060 )
• in pIpC-treated mice
decreased hematocrit ( J:179060 )
• in pIpC-treated mice
decreased hemoglobin content ( J:179060 )
• in pIpC-treated mice
decreased T cell number ( J:179060 )
• in pIpC-treated mice
increased leukocyte cell number ( J:179060 )
• in pIpC-treated mice
increased neutrophil cell number ( J:179060 )
• in pIpC-treated mice
abnormal spleen morphology ( J:179060 )
• pIpC-treated mice exhibit myeloid infiltration in the spleen unlike in control mice
enlarged spleen ( J:179060 )
• severe in pIpC-treated mice with expansion of red pulp
increased spleen weight ( J:179060 )
• in pIpC-treated mice
spleen hyperplasia ( J:179060 )
• in pIpC-treated mice
increased spleen red pulp amount ( J:179060 )
• in pIpC-treated mice

skeleton
abnormal bone marrow morphology ( J:179060 )
• metatarsal bone marrow in pIpC-treated mice is filled with hematopoietic cells instead of being replaced with fat cells as in control mice

cellular
abnormal granulocyte differentiation ( J:179060 )
• non-cell-autonomous in pIpC-treated mice

immune system
abnormal granulocyte differentiation ( J:179060 )
• non-cell-autonomous in pIpC-treated mice
small thymus ( J:179060 )
• in pIpC-treated mice
thymus hypoplasia ( J:179060 )
• in pIpC-treated mice
abnormal T cell differentiation ( J:179060 )
• at an early stage in pIpC-treated mice
myeloid hyperplasia ( J:179060 )
• pIpC-treated mice exhibit an increase in Gr1+CD11b+ myeloid cells in the spleen compared with control mice
• however, no difference was observed in the bone marrow
decreased T cell number ( J:179060 )
• in pIpC-treated mice
increased leukocyte cell number ( J:179060 )
• in pIpC-treated mice
increased neutrophil cell number ( J:179060 )
• in pIpC-treated mice
abnormal spleen morphology ( J:179060 )
• pIpC-treated mice exhibit myeloid infiltration in the spleen unlike in control mice
enlarged spleen ( J:179060 )
• severe in pIpC-treated mice with expansion of red pulp
increased spleen weight ( J:179060 )
• in pIpC-treated mice
spleen hyperplasia ( J:179060 )
• in pIpC-treated mice
increased spleen red pulp amount ( J:179060 )
• in pIpC-treated mice

endocrine/exocrine glands
small thymus ( J:179060 )
• in pIpC-treated mice
thymus hypoplasia ( J:179060 )
• in pIpC-treated mice

growth/size/body
enlarged spleen ( J:179060 )
• severe in pIpC-treated mice with expansion of red pulp
increased spleen weight ( J:179060 )
• in pIpC-treated mice
spleen hyperplasia ( J:179060 )
• in pIpC-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory