All Phenotypes Foxo1<tm2.1Dac> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxo1^tm2.1Dac/Foxo1^tm2.1Dac	B6.Cg-Foxo1^tm2.1Dac	MGI:5305586
hm2	Foxo1^tm2.1Dac/Foxo1^tm2.1Dac	Not Specified	MGI:5305585
cx3	Foxo1^tm2.1Dac/Foxo1^tm2.1Dac Lepr^db/Lepr^db	B6.Cg-Foxo1^tm2.1Dac Lepr^db	MGI:5305587
cx4	Foxo1^tm2.1Dac/Foxo1^tm2.1Dac Insr^tm1Dac/Insr⁺	involves: 129S4/SvJae * C57BL/6	MGI:5305588

Allelic Composition	Foxo1^tm2.1Dac/Foxo1^tm2.1Dac
Genetic Background	B6.Cg-Foxo1^tm2.1Dac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm2.1Dac mutation (0 available); any Foxo1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:179687 )

• in mice fed a high-fat diet

decreased circulating tumor necrosis factor level ( J:179687 )

• in mice fed a high-fat diet

decreased liver cholesterol level ( J:179687 )

• in mice fed a high-fat diet

growth/size/body

increased susceptibility to diet-induced obesity ( J:179687 )

• in mice fed a high-fat diet

adipose tissue

increased percent body fat/body weight ( J:179687 )

• in mice fed a high-fat diet

immune system

decreased circulating tumor necrosis factor level ( J:179687 )

• in mice fed a high-fat diet

liver/biliary system

decreased liver cholesterol level ( J:179687 )

• in mice fed a high-fat diet

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased energy expenditure ( J:179687 )

• in resting mice

decreased carbon dioxide production ( J:179687 )

decreased respiratory quotient ( J:179687 )

abnormal glucose homeostasis ( J:179687 )

• mice exhibit decreased glucose infusion rates compared with wild-type mice

• however, mice exhibit normal whole body glucose uptake and glycolysis

increased circulating glucose level ( J:179687 )

• in fasting and re-fed mice

increased circulating insulin level ( J:179687 )

• in fasting, but not re-fed, mice

abnormal gluconeogenesis ( J:179687 )

• under maximal insulin concentrations, hepatic glucose production is 2.5-fold compared to in wild-type mice

insulin resistance ( J:179687 )

abnormal lipid homeostasis ( J:179687 )

• de novo lipogenesis is decreased compared to in wild-type mice

decreased circulating cholesterol level ( J:179687 )

• in fasting mice

decreased circulating free fatty acids level ( J:179687 )

• in fasting and re-fed mice

decreased circulating triglyceride level ( J:179687 )

• in re-fed, but not fasting, mice

decreased circulating VLDL triglyceride level ( J:179687 )

decreased liver triglyceride level ( J:179687 )

• in re-fed mice

adipose tissue

abnormal adipose tissue physiology ( J:179687 )

• isoproterenol-stimulated glycerol release from cultured epididymal fat pads is increased compared to in wild-type cells

• however, basal levels are normal

liver/biliary system

decreased liver triglyceride level ( J:179687 )

• in re-fed mice

Allelic Composition	Foxo1^tm2.1Dac/Foxo1^tm2.1Dac Lepr^db/Lepr^db
Genetic Background	B6.Cg-Foxo1^tm2.1Dac Lepr^db

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm2.1Dac mutation (0 available); any Foxo1 mutation (32 available)
Lepr^db mutation (17 available); any Lepr mutation (122 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:179687 )

• in fasted mice

impaired glucose tolerance ( J:179687 )

Allelic Composition	Foxo1^tm2.1Dac/Foxo1^tm2.1Dac Insr^tm1Dac/Insr⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm2.1Dac mutation (0 available); any Foxo1 mutation (32 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:179687 )

• in fasted and re-fed mice

insulin resistance ( J:179687 )

• slightly impaired hypoglycemic response in an insulin intolerance test

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