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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Id3tm2.1Cmu
targeted mutation 2.1, Cornelis Murre
MGI:5305600
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Id3tm2.1Cmu/Id3tm2.1Cmu Not Specified MGI:5305603
cn2
 		Id3tm2.1Cmu/Id3tm2.1Cmu
Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Cd4-cre)1Cwi/0 		involves: 129S4/SvJaeSor * C57BL/6 * DBA/2 MGI:5305604
cx3
 		Id2tm2.1Ago/Id2+
Id3tm2.1Cmu/Id3+ 		involves: C57BL/6 MGI:5305688


Genotype
MGI:5305603
hm1
Allelic
Composition		 Id3tm2.1Cmu/Id3tm2.1Cmu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id3tm2.1Cmu mutation (0 available); any Id3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:176462 )
• B220+CXCR5+ cells in the thymus
increased T follicular helper cell number ( J:176462 )
• more thymocytes express markers associated with innate-like and effector-memory-like phenotypes compared to in wild-type mice
increased gamma-delta T cell number ( J:176462 )
• increased proportion in the thymus

hematopoietic system
increased B cell number ( J:176462 )
• B220+CXCR5+ cells in the thymus
increased T follicular helper cell number ( J:176462 )
• more thymocytes express markers associated with innate-like and effector-memory-like phenotypes compared to in wild-type mice
increased gamma-delta T cell number ( J:176462 )
• increased proportion in the thymus

endocrine/exocrine glands




Genotype
MGI:5305604
cn2
Allelic
Composition		 Id3tm2.1Cmu/Id3tm2.1Cmu
Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id3tm2.1Cmu mutation (0 available); any Id3 mutation (16 available)
Tcf3tm4Zhu mutation (2 available); any Tcf3 mutation (43 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:176462 )
N
• T follicular helper cell development is restored compared with Id3tm2.1Cmu homozygotes
decreased thymocyte number ( J:176462 )
• partially restored compared with Id3tm2.1Cmu homozygotes

hematopoietic system
decreased thymocyte number ( J:176462 )
• partially restored compared with Id3tm2.1Cmu homozygotes

endocrine/exocrine glands
decreased thymocyte number ( J:176462 )
• partially restored compared with Id3tm2.1Cmu homozygotes




Genotype
MGI:5305688
cx3
Allelic
Composition		 Id2tm2.1Ago/Id2+
Id3tm2.1Cmu/Id3+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm2.1Ago mutation (0 available); any Id2 mutation (21 available)
Id3tm2.1Cmu mutation (0 available); any Id3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:179006 )
N
• CD8+ T cells exhibit normal responses




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory