Phenotypes associated with this allele

• Allele Symbol: Arhgef6^tm1Kkut
• Allele Name: targeted mutation 1, Kerstin Kutsche
• Allele ID: MGI:5305716
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Arhgef6^tm1Kkut/Y	B6.129-Arhgef6^tm1Kkut	MGI:5305722

Genotype
MGI:5305722

ot1

• Allelic Composition: Arhgef6^tm1Kkut/Y
• Genetic Background: B6.129-Arhgef6^tm1Kkut

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dendrite morphology ( J:179026 )

♂ • at 8 weeks, mice exhibit increased dendrite length (total and basal), and segment length (apical and basal) in the hippocampus CA1 compared with wild-type mice

♂ • at 12 weeks, mice exhibit increased dendrite length (total, apical, and basal), number of branch points per dendrite (basal and apical), and terminal segment length (apical and basal) in hippocampal area CA1 compared with wild-type mice

♂ • at 12 weeks, basal dendrites exhibit a modest increase in length due to mild increases in the number of branch points and in the length of terminal and intermediate segments in the primary visual cortex compared to in wild-type dendrites

♂ • however, the number of dendrites per neuron is normal

abnormal dendritic spine morphology ( J:179026 )

♂ • the number of dendrite spines is increased in hippocampal area CA1 compared to in wild-type mice

♂ • spine neck length is slightly increased in hippocampal area CA1 compared to in wild-type mice

abnormal synapse morphology ( J:179026 )

♂ • from 10 weeks onward, mice exhibit a loss of synapse density per unit volume in hippocampal area CA1 compared with wild-type mice

reduced long-term potentiation ( J:179026 )

♂ • reduced early-phase

abnormal long-term depression ( J:179026 )

♂ • increased

behavior/neurological

behavior/neurological phenotype ( J:179026 )

♂N • mice exhibit spatial working memory in an eight-arm radial maze

♂N • mice exhibit normal activity and anxiety-related behavior in a novel environment

abnormal spatial learning ( J:179026 )

♂ • in a Morris water maze, mice exhibit navigation errors and spatial perseverance compared with wild-type mice

♂ • in IntelliCage, mice exhibit impaired complex positional learning compared with wild-type mice

abnormal response to novel object ( J:179026 )

♂ • mice exhibit disinhibited object exploration compared with wild-type mice