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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Acta2-cre/ERT2)#Pcn
transgene insertion, Pierre Chambon
MGI:5305721
Summary 2 genotypes


Genotype
MGI:5927438
cn1
Allelic
Composition		 Tg(Acta2-cre/ERT2)#Pcn/0
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(H2-K-Fosl2,-EGFP)13Wag/0
Genetic
Background		 B6.Cg-Tgfbr2tm1Karl Tg(Acta2-cre/ERT2)#Pcn Tg(H2-K-Fosl2,-EGFP)13Wag
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Acta2-cre/ERT2)#Pcn mutation (0 available)
Tgfbr2tm1Karl mutation (1 available); any Tgfbr2 mutation (40 available)
Tg(H2-K-Fosl2,-EGFP)13Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
lung inflammation ( J:238723 )
• mice treated with tamoxifen show similar lung inflammation as single Tg(H2-K-Fosl2,EGFP)13Wag mice
pulmonary fibrosis ( J:238723 )
• mice treated with tamoxifen show similar pulmonary fibrosis as single Tg(H2-K-Fosl2,EGFP)13Wag mice

immune system
lung inflammation ( J:238723 )
• mice treated with tamoxifen show similar lung inflammation as single Tg(H2-K-Fosl2,EGFP)13Wag mice

cardiovascular system
cardiovascular system phenotype ( J:238723 )
N
• mice treated with tamoxifen show diminished expansion of the smooth muscle cell area in pulmonary arteries and reduced proliferation of pulmonary artery smooth muscle cells that is seen in single Tg(H2-K-Fosl2,EGFP)13Wag mice




Genotype
MGI:5475012
cn2
Allelic
Composition		 Nr3c2tm1.1Ics/Nr3c2tm1.1Ics
Tg(Acta2-cre/ERT2)#Pcn/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c2tm1.1Ics mutation (1 available); any Nr3c2 mutation (53 available)
Tg(Acta2-cre/ERT2)#Pcn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:193438 )
N
• tamoxifen-treated mice exhibit normal vascular structure and blood pressure response to altered sodium content diets
decreased heart weight ( J:193438 )
• aged tamoxifen-treated mice do not develop cardiac hypertrophy unlike control mice
decreased systemic arterial systolic blood pressure ( J:193438 )
• in tamoxifen-treated mice by 7 months of age
• in adult and aged tamoxifen-treated mice in response to Ang II
• however, diurnal blood pressure variation is normal
abnormal vasoconstriction ( J:193438 )
• aged tamoxifen-treated mice fail to exhibit an increase in contraction response to KCL or U46619 (thromboxane receptor agonist) unlike control mice
• however, the age-dependent increase in contraction response to phenylephrine is preserved
decreased vasoconstriction ( J:193438 )
• in tamoxifen-treated mice in response to phenylephrine
• in adult tamoxifen-treated mice in response to acetylcholine
• in aged tamoxifen-treated mice in response to BayK8644 (L-type calcium channel agonist)
• in adult and aged tamoxifen-treated mice in response to Ang II
increased vasoconstriction ( J:193438 )
• in aged tamoxifen-treated mice in response to sodium nitroprusside
abnormal vasodilation ( J:193438 )
• aged tamoxifen-treated mice exhibit a modest decrease in endothelial cell-independent vasodilation compared with control mice
increased vasodilation ( J:193438 )
• endothelial-dependent tamoxifen-treated mice

renal/urinary system
renal/urinary system phenotype ( J:193438 )
N
• tamoxifen-treated mice exhibit intact renal function

cellular
abnormal redox activity ( J:193438 )
• adult tamoxifen-treated mice exhibit attenuated AngII-stimulated reactive oxygen species production compared with control mice
• aged tamoxifen-treated mice exhibit attenuated reactive oxygen species production prior to and after AngII-stimulation compared with control mice

muscle
abnormal vasoconstriction ( J:193438 )
• aged tamoxifen-treated mice fail to exhibit an increase in contraction response to KCL or U46619 (thromboxane receptor agonist) unlike control mice
• however, the age-dependent increase in contraction response to phenylephrine is preserved
decreased vasoconstriction ( J:193438 )
• in tamoxifen-treated mice in response to phenylephrine
• in adult tamoxifen-treated mice in response to acetylcholine
• in aged tamoxifen-treated mice in response to BayK8644 (L-type calcium channel agonist)
• in adult and aged tamoxifen-treated mice in response to Ang II
increased vasoconstriction ( J:193438 )
• in aged tamoxifen-treated mice in response to sodium nitroprusside
abnormal vasodilation ( J:193438 )
• aged tamoxifen-treated mice exhibit a modest decrease in endothelial cell-independent vasodilation compared with control mice
increased vasodilation ( J:193438 )
• endothelial-dependent tamoxifen-treated mice
abnormal muscle tone ( J:193438 )
• aged tamoxifen-treated mice develop less spontaneous myogenic tone compared with control mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory