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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apctm2.1Alew
targeted mutation 1.1, Anabelle Lewis
MGI:5305728
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Apctm2.1Alew/Apctm2.1Alew B6.129-Apctm2.1Alew MGI:5306024
ht2
 		Apctm2.1Alew/Apc+ B6.129-Apctm2.1Alew MGI:5306025


Genotype
MGI:5306024
hm1
Allelic
Composition		 Apctm2.1Alew/Apctm2.1Alew
Genetic
Background		 B6.129-Apctm2.1Alew
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2.1Alew mutation (0 available); any Apc mutation (158 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:180057 )
• mice die early in gestation




Genotype
MGI:5306025
ht2
Allelic
Composition		 Apctm2.1Alew/Apc+
Genetic
Background		 B6.129-Apctm2.1Alew
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2.1Alew mutation (0 available); any Apc mutation (158 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor pathology ( J:180057 )
• indistinguishable from Apctm1.1Alew heterozygotes
• however, no carcinomas are observed
increased adenoma incidence ( J:180057 )
• gastric and intestinal

digestive/alimentary system
gastrointestinal tract polyps ( J:180057 )
• majority in the duodenum and jejunum

behavior/neurological

hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory