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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tdrd6tm1Chum
targeted mutation 1, Shinichiro Chuma
MGI:5305938
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tdrd6tm1Chum/Tdrd6tm1Chum involves: 129S4/SvJae * C57BL/6 MGI:5305958
cx2
 		Tdrd6tm1Chum/Tdrd6tm1Chum
Tdrd7tm1.1Chum/Tdrd7tm1.1Chum 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:5305959


Genotype
MGI:5305958
hm1
Allelic
Composition		 Tdrd6tm1Chum/Tdrd6tm1Chum
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tdrd6tm1Chum mutation (1 available); any Tdrd6 mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Spermiogenesis defect in Tdrd6tm1Chum/Tdrd6tm1Chum males

reproductive system
arrest of spermatogenesis ( J:173550 )
• spermatids proceed through round stage and into an elongation stage




Genotype
MGI:5305959
cx2
Allelic
Composition		 Tdrd6tm1Chum/Tdrd6tm1Chum
Tdrd7tm1.1Chum/Tdrd7tm1.1Chum
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tdrd6tm1Chum mutation (1 available); any Tdrd6 mutation (81 available)
Tdrd7tm1.1Chum mutation (1 available); any Tdrd7 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Initial assembly of chromatoid bodies is disrupted in Tdrd6tm1Chum/Tdrd6tm1Chum Tdrd7tm1.1Chum/Tdrd7tm1.1Chum mice

reproductive system
arrest of spermatogenesis ( J:173550 )
• at round spermatid stage
• chromatoid bodies completely absent from early assembly stage in spermatocytes to late stage haploid spermatids




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory