About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir34atm1.1Aven
targeted mutation 1.1, Andrea Ventura
MGI:5305966
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mir34atm1.1Aven/Mir34atm1.1Aven involves: 129S4/SvJae * C57BL/6 MGI:5305967
cx2
 		Mir34atm1.1Aven/Mir34atm1.1Aven
Mirc21tm1.1Aven/Mirc21tm1.1Aven
Mirc34em1Jnch/Mirc34em1Jnch
Tg(Hlxb9-GFP)1Tmj/0 		involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N MGI:6696405
cx3
 		Mir34atm1.1Aven/Mir34atm1.1Aven
Mirc21tm1.1Aven/Mirc21tm1.1Aven
Mirc34em1Jnch/Mirc34em1Jnch 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:6696404


Genotype
MGI:5305967
hm1
Allelic
Composition		 Mir34atm1.1Aven/Mir34atm1.1Aven
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir34atm1.1Aven mutation (0 available); any Mir34a mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal precursor proliferation ( J:180144 )
• decrease in the proliferation of precursors in the subgranular zone of the dentate gyrus

cellular
abnormal neuronal precursor proliferation ( J:180144 )
• decrease in the proliferation of precursors in the subgranular zone of the dentate gyrus




Genotype
MGI:6696405
cx2
Allelic
Composition		 Mir34atm1.1Aven/Mir34atm1.1Aven
Mirc21tm1.1Aven/Mirc21tm1.1Aven
Mirc34em1Jnch/Mirc34em1Jnch
Tg(Hlxb9-GFP)1Tmj/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir34atm1.1Aven mutation (0 available); any Mir34a mutation (9 available)
Mirc21tm1.1Aven mutation (1 available); any Mirc21 mutation (5 available)
Mirc34em1Jnch mutation (0 available); any Mirc34 mutation (1 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:304721 )
N
• mice exhibit normal motor neuron development




Genotype
MGI:6696404
cx3
Allelic
Composition		 Mir34atm1.1Aven/Mir34atm1.1Aven
Mirc21tm1.1Aven/Mirc21tm1.1Aven
Mirc34em1Jnch/Mirc34em1Jnch
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir34atm1.1Aven mutation (0 available); any Mir34a mutation (9 available)
Mirc21tm1.1Aven mutation (1 available); any Mirc21 mutation (5 available)
Mirc34em1Jnch mutation (0 available); any Mirc34 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:304721 )
• lethality occurs between P21 to P28 in some mice
postnatal lethality, incomplete penetrance ( J:304721 )
• lethality occurs between P7 and P14

behavior/neurological
jumpy ( J:304721 )
• in home cages and open arena
abnormal locomotor coordination ( J:304721 )
• uncoordinated hind tiptoe walking
decreased locomotor activity ( J:304721 )
• slight
• however, mice exhibit normal locomotor coordination running speed, temporal composition during the step cycle, and inter-limb coordination

nervous system
nervous system phenotype ( J:304721 )
N
• mice exhibit normal motor neuron numbers
abnormal motor neuron morphology ( J:304721 )
• mice exhibit altered number of sub-population of motor synergy encoder neurons compared with wild-type mice

growth/size/body
decreased body weight ( J:304721 )
postnatal growth retardation ( J:304721 )

vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory