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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Neil3tm1Bjor
targeted mutation 1, Magnar Bjoras
MGI:5306033
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Neil3tm1Bjor/Neil3tm1Bjor involves: 129 * C57BL/6 MGI:5306040


Genotype
MGI:5306040
hm1
Allelic
Composition		 Neil3tm1Bjor/Neil3tm1Bjor
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neil3tm1Bjor mutation (0 available); any Neil3 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Reduced neuronal regeneration after perinatal hypoxic-ischemia in Neil3tm1Bjor/Neil3tm1Bjor mice

nervous system
abnormal neuron differentiation ( J:180177 )
• neurospheres exhibit poor growth and skewed differentiation compared with wild-type neurospheres
abnormal neuronal precursor proliferation ( J:180177 )
• decreased proliferation following induction of hypoxia-ischemia
decreased microglial cell activation ( J:180177 )
• decreased following induction of hypoxia-ischemia
increased cerebral infarct size ( J:180177 )
• 2.6-fold larger following induction of hypoxia-ischemia
decreased neuronal precursor cell number ( J:180177 )
• in the striatum following induction of hypoxia-ischemia

homeostasis/metabolism
abnormal DNA repair ( J:180177 )
• paraquat-treated neurospheres exhibit increased accumulation of strand breaks compared with wild-type cells
• however, brains do not accumulate double-strand breaks
increased cerebral infarct size ( J:180177 )
• 2.6-fold larger following induction of hypoxia-ischemia

immune system
decreased microglial cell activation ( J:180177 )
• decreased following induction of hypoxia-ischemia

cellular
abnormal neuron differentiation ( J:180177 )
• neurospheres exhibit poor growth and skewed differentiation compared with wild-type neurospheres
abnormal neuronal precursor proliferation ( J:180177 )
• decreased proliferation following induction of hypoxia-ischemia
abnormal DNA repair ( J:180177 )
• paraquat-treated neurospheres exhibit increased accumulation of strand breaks compared with wild-type cells
• however, brains do not accumulate double-strand breaks

hematopoietic system
decreased microglial cell activation ( J:180177 )
• decreased following induction of hypoxia-ischemia




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory