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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Igf1rtm2.1Arge
targeted mutation 2.1, Argiris Efstratiadis
MGI:5306047
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Igf1rtm2.1Arge/Igf1rtm2.1Arge involves: 129 * C57BL/6 MGI:5306153


Genotype
MGI:5306153
hm1
Allelic
Composition
Igf1rtm2.1Arge/Igf1rtm2.1Arge
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm2.1Arge mutation (0 available); any Igf1r mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die immediately after birth of respiratory failure

hearing/vestibular/ear
• noticeably smaller and flattened
• posterior canal is obscured
• shortened and slightly widened
• 33% shorter
• decreased proliferation of prosensory cells, by 69% at E12.5 and by 54% at E13.5
• delayed development of hair cells and support cells
• but hair cell density is normal
• sometimes not aligned properly
• luminal surfaces are smaller
• lateral migration is delayed
• luminal surfaces are smaller
• truncated but lateral crista intact
• hypomorphic but posterior crista are normal

growth/size/body
• severe intrauterine growth deficiency
• embryos are only about 1/2 the size of heterozygotes

respiratory system
• die immediately after birth of respiratory failure

nervous system
• delayed development of hair cells and support cells
• but hair cell density is normal
• sometimes not aligned properly
• luminal surfaces are smaller
• lateral migration is delayed
• luminal surfaces are smaller

cellular
• lateral migration is delayed

skeleton
• noticeably smaller and flattened
• posterior canal is obscured

craniofacial
• noticeably smaller and flattened
• posterior canal is obscured





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory