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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		m1078Lja
mutation 1078, J Larry Jameson
MGI:5306137
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		m1078Lja/m1078Lja involves: C57BL/6J * DBA MGI:5306141


Genotype
MGI:5306141
hm1
Allelic
Composition		 m1078Lja/m1078Lja
Genetic
Background		 involves: C57BL/6J * DBA
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Hypogonadism with germ cell deficiency in m1078Lja/m1078Lja males

reproductive system
decreased male germ cell number ( J:179895 )
• every tubule exhibits substantial germ cell deficiency
• the most affected tubules containing only Sertoli cells while other tubules contain only premeiotic cells many tubules contain cells with condensed, pyknotic nuclei
small testis ( J:179895 )
• severe hypogonadism in males

endocrine/exocrine glands
small testis ( J:179895 )
• severe hypogonadism in males

cellular
decreased male germ cell number ( J:179895 )
• every tubule exhibits substantial germ cell deficiency
• the most affected tubules containing only Sertoli cells while other tubules contain only premeiotic cells many tubules contain cells with condensed, pyknotic nuclei




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory