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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prdm9M1045Lja
mutation 1045, J Larry Jameson
MGI:5306140
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prdm9M1045Lja/Prdm9M1045Lja involves: C57BL/6J * DBA MGI:5306143
ht2
 		Prdm9M1045Lja/Prdm9+ involves: C57BL/6J * DBA MGI:5306145


Genotype
MGI:5306143
hm1
Allelic
Composition		 Prdm9M1045Lja/Prdm9M1045Lja
Genetic
Background		 involves: C57BL/6J * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm9M1045Lja mutation (0 available); any Prdm9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Incomplete dominance with spermatogenic block in Prdm9M1045Lja/Prdm9+ mice or germ cell loss in Prdm9M1045Lja/Prdm9M1045Lja mice

reproductive system
abnormal germ cell morphology ( J:179895 )
• germ cells in seminiferous tubules are all premeiotic
• some nuclei are pyknotic
azoospermia ( J:179895 )
• no germ cells are seen in the epididymis
small testis ( J:179895 )
• severe hypogonadism
decreased testis weight ( J:179895 )
• mean testis weight is 33 mg compared to 102 mg for controls

endocrine/exocrine glands
small testis ( J:179895 )
• severe hypogonadism
decreased testis weight ( J:179895 )
• mean testis weight is 33 mg compared to 102 mg for controls

cellular
abnormal germ cell morphology ( J:179895 )
• germ cells in seminiferous tubules are all premeiotic
• some nuclei are pyknotic
azoospermia ( J:179895 )
• no germ cells are seen in the epididymis




Genotype
MGI:5306145
ht2
Allelic
Composition		 Prdm9M1045Lja/Prdm9+
Genetic
Background		 involves: C57BL/6J * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm9M1045Lja mutation (0 available); any Prdm9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Incomplete dominance with spermatogenic block in Prdm9M1045Lja/Prdm9+ mice or germ cell loss in Prdm9M1045Lja/Prdm9M1045Lja mice

reproductive system
abnormal spermatid morphology ( J:179895 )
• absence of elongated spermatids in the tubules
decreased male germ cell number ( J:179895 )
• absence of sperm in the epididymides
small testis ( J:179895 )
• mild hypogonadism in males
abnormal spermiogenesis ( J:179895 )
• late spermatogenic block precluding spermiogenesis

endocrine/exocrine glands
small testis ( J:179895 )
• mild hypogonadism in males

cellular
abnormal spermatid morphology ( J:179895 )
• absence of elongated spermatids in the tubules
decreased male germ cell number ( J:179895 )
• absence of sperm in the epididymides




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory