Phenotypes associated with this allele

• Allele Symbol: Col1a1^{tm8(CAG-BDNF)Jae}
• Allele Name: targeted mutation 8, Rudolf Jaenisch
• Allele ID: MGI:5306239
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Col1a1^tm8(CAG-BDNF)Jae/Col1a1^+ Mecp2^tm1.1Jae/Y Tg(Camk2a-cre)93Kln/0	involves: 129S4/SvJae * C57BL/6 * CBA/J	MGI:5306257
cn2	Col1a1^tm8(CAG-BDNF)Jae/Col1a1^tm8(CAG-BDNF)Jae Tg(Sim1-cre)1Lowl/0	involves: 129S4/SvJae * C57BL/6 * FVB	MGI:5306345

Genotype
MGI:5306257

cn1

• Allelic Composition: Col1a1^{tm8(CAG-BDNF)Jae}/Col1a1⁺; Mecp2^tm1.1Jae/Y; Tg(Camk2a-cre)93Kln/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:106973 )

♂ • life span is significantly longer than in Mecp2 single hemizygous mice

behavior/neurological

behavior/neurological phenotype ( J:106973 )

♂N • overexpression of BDNF improves locomotor function compared to Mecp2 single hemizygous mice at 6 weeks of age

nervous system

decreased brain weight ( J:106973 )

♂ • decreased compared to wild-type littermates but modestly increased compared to Mecp2 single hemizygous mice

abnormal action potential ( J:106973 )

♂ • firing rate is increased compared to Mecp2 single hemizygous mice

Genotype
MGI:5306345

cn2

• Allelic Composition: Col1a1^{tm8(CAG-BDNF)Jae}/Col1a1^{tm8(CAG-BDNF)Jae}; Tg(Sim1-cre)1Lowl/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

nervous system

abnormal hypothalamus physiology ( J:179918 )

• elevated immunoreactivity for corticotropin-releasing hormone in the paraventricular nucleus

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:179918 )

N • despite increase in corticotropin-releasing hormone levels in the paraventricular nucleus, circulating adrenocorticotropin and corticosterone are largely unaffected