mortality/aging
hematopoietic system
Allele Symbol Allele Name Allele ID |
Kitltm2.2Sjm targeted mutation 2.2, Sean J Morrison MGI:5306338 |
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Summary |
7 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal blood cell counts and bone marrow and spleen cellularity
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• to a greater extent than in Kitltm2.2Sjm heterozygotes in the bone marrow
• 1.7-2.1-fold in the liver of newborn mice
• 2-fold in the bone marrow of 1 month old mice
• 2.7-5.2-fold in the bone marrow of 8 week old mice
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• bone marrow cells from tamoxifen-treated mice used to repopulate irradiated mice exhibit reduced bone marrow-derived cell production (total, myeloid, T cell, and B cell)
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• exhibit normal blood cell counts, bone marrow composition, bone marrow and spleen cellularity, and reconstitution capacity
|
• 2-fold as in Kitltm2.2Sjm heterozygotes in the bone marrow
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• tamoxifen-treated mice exhibit normal hematopoiesis, hematopoietic stem cell frequency, and reconstitution capacity
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal blood cell counts, bone marrow composition, bone marrow and spleen cellularity, and reconstitution capacity
• unlike Kitltm2.2Sjm heterozygotes, mice exhibit normal numbers of hematopoietic stem cells in the spleen
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|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• exhibit normal blood cell counts, bone marrow composition, bone marrow and spleen cellularity, and reconstitution capacity
|
• 2-fold as in Kitltm2.2Sjm heterozygotes in the bone marrow
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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