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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc24a4tm1.2Hazh
targeted mutation 1.2, Haiqing Zhao
MGI:5306365
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh
Omptm4(cre)Mom/Omptm4(cre)Mom 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 MGI:5306367
cn2
 		Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh
Omptm4(cre)Mom/Omp+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 MGI:5306368


Genotype
MGI:5306367
cn1
Allelic
Composition		 Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh
Omptm4(cre)Mom/Omptm4(cre)Mom
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm4(cre)Mom mutation (2 available); any Omp mutation (27 available)
Slc24a4tm1.2Hazh mutation (0 available); any Slc24a4 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:180325 )
• extreme




Genotype
MGI:5306368
cn2
Allelic
Composition		 Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh
Omptm4(cre)Mom/Omp+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm4(cre)Mom mutation (2 available); any Omp mutation (27 available)
Slc24a4tm1.2Hazh mutation (0 available); any Slc24a4 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal olfactory system physiology ( J:180325 )
• olfactory sensory neurons exhibit prolonged termination compared with control cells
impaired olfaction ( J:180325 )
• mice exhibit reduced ability to locate odors, as indicated by decreased body weight at weaning, compared with control mice
• mice exhibit impaired ability to find a buried pellet compared with control mice
• however, mice normally locate a visible pellet

nervous system
abnormal sensory neuron physiology ( J:180325 )
• olfactory sensory neurons exhibit prolonged termination compared with control cells

growth/size/body
decreased body weight ( J:180325 )
• at weaning likely due to impaired olfaction




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory