behavior/neurological
• as early as 6 weeks of age in a rotarod test
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Allele Symbol Allele Name Allele ID |
Eif2b5tm1Itl targeted mutation 1, InGenious Targeting Laboratory MGI:5306369 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• as early as 6 weeks of age in a rotarod test
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• primary microglial cells exhibit impaired production of cytokines in response to LPS
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• primary microglial cells exhibit impaired production of cytokines in response to LPS
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• primary microglial cells exhibit impaired production of cytokines in response to LPS
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• astrocyte cultures treated with LPS show abnormal morphology, remaining flat shaped rather than star shape in response to activation
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• mice exhibit impaired astrogliosis in response to systemic stress induced by lipopolysaccharide (LPS)
• primary astrocytes exhibit impaired production of cytokines in response to LPS
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
leukoencephalopathy with vanishing white matter | DOID:0060868 |
OMIM:PS603896 |
J:192103 |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• abnormal development of brain white matter
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• as detected by MRI
• however, older mice exhibit normal isotropy values in an MRI
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• decreased astrocyte numbers at 3 weeks but not 4 months
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• at 3 weeks but not 4 months
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• young mice exhibit a higher portion of small-caliber axons compared with wild-type mice
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• late-onset myelin degeneration
• impaired recovery from cuprizone-induced demyelination
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• impaired recovery from cuprizone-induced demyelination
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
leukoencephalopathy with vanishing white matter | DOID:0060868 |
OMIM:PS603896 |
J:179801 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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