Phenotypes associated with this allele

• Allele Symbol: Sesn1^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:5306501
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sesn1^tm1a(EUCOMM)Wtsi/Sesn1^tm1a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5905768

Genotype
MGI:5905768

hm1

• Allelic Composition: Sesn1^{tm1a(EUCOMM)Wtsi}/Sesn1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0052_5_G07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:240602 )

• following subcutaneous challenge with FLUAD in 20 month old mice

enlarged spleen ( J:240602 )

• following subcutaneous challenge with FLUAD in 20 month old mice

abnormal class switch recombination ( J:240602 )

• enhanced IgG isotypic switching in B cells following subcutaneous challenge with FLUAD (a trivalent inactivated influenza human vaccine that is also effective in rodents) in 20 month old mice

decreased B cell number ( J:240602 )

• slightly lower frequencies in the spleen of mice following subcutaneous challenge with FLUAD in 20 month old mice

abnormal effector T cell number ( J:240602 )

• following subcutaneous challenge with FLUAD in 20 month old mice, mice exhibit a 2-fold increase in CD62L-CD44+ T effector cells with a decrease in CD62L+CD44- naive T cells compared with control mice

increased NK T cell number ( J:240602 )

• 2-fold following subcutaneous challenge with FLUAD in 20 month old mice

increased single-positive T cell number ( J:240602 )

• 2-fold increase in frequency of splenic CD4+ and CD8+ T cells following subcutaneous challenge with FLUAD in 20 month old mice

increased splenocyte number ( J:240602 )

• 3-fold following subcutaneous challenge with FLUAD in 20 month old mice

increased immunoglobulin level ( J:240602 )

• 2- to 3-fold increase in influenza-specific circulating IgGs following subcutaneous challenge with FLUAD in 20 month old mice

increased interferon-gamma secretion ( J:240602 )

• in CD4+ T cells following subcutaneous challenge with FLUAD or antigen-specific vaccination and re-challenge in 20 month old mice

increased interleukin-2 secretion ( J:240602 )

• in CD4+ T cells following subcutaneous challenge with FLUAD or antigen-specific vaccination and re-challenge in 20 month old mice

hematopoietic system

increased T cell proliferation ( J:240602 )

• following subcutaneous challenge with FLUAD in 20 month old mice

enlarged spleen ( J:240602 )

• following subcutaneous challenge with FLUAD in 20 month old mice

abnormal class switch recombination ( J:240602 )

• enhanced IgG isotypic switching in B cells following subcutaneous challenge with FLUAD (a trivalent inactivated influenza human vaccine that is also effective in rodents) in 20 month old mice

decreased B cell number ( J:240602 )

• slightly lower frequencies in the spleen of mice following subcutaneous challenge with FLUAD in 20 month old mice

abnormal effector T cell number ( J:240602 )

• following subcutaneous challenge with FLUAD in 20 month old mice, mice exhibit a 2-fold increase in CD62L-CD44+ T effector cells with a decrease in CD62L+CD44- naive T cells compared with control mice

increased NK T cell number ( J:240602 )

• 2-fold following subcutaneous challenge with FLUAD in 20 month old mice

increased single-positive T cell number ( J:240602 )

• 2-fold increase in frequency of splenic CD4+ and CD8+ T cells following subcutaneous challenge with FLUAD in 20 month old mice

increased myeloid cell number ( J:240602 )

• 5-fold following subcutaneous challenge with FLUAD in 20 month old mice

increased splenocyte number ( J:240602 )

• 3-fold following subcutaneous challenge with FLUAD in 20 month old mice

increased immunoglobulin level ( J:240602 )

• 2- to 3-fold increase in influenza-specific circulating IgGs following subcutaneous challenge with FLUAD in 20 month old mice

cellular

increased T cell proliferation ( J:240602 )

• following subcutaneous challenge with FLUAD in 20 month old mice

growth/size/body

enlarged spleen ( J:240602 )

• following subcutaneous challenge with FLUAD in 20 month old mice