All Phenotypes Trp53<tm1.1Dgk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53^tm1.1Dgk
targeted mutation 1.1, David G Kirsch
MGI:5306612

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Trp53^tm1Tyj/Trp53^tm1.1Dgk	involves: 129S * 129X1/SvJ * C57BL/6	MGI:5306614
cn2	Kras^tm5Tyj/Kras⁺ Pdx1^{tm1.1(flpo)Most}/Pdx1⁺ Trp53^tm1.1Dgk/Trp53⁺	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6	MGI:6273511
cn3	Kras^tm5Tyj/Kras⁺ Pdx1^{tm1.1(flpo)Most}/Pdx1⁺ Trp53^tm1.1Dgk/Trp53^tm1.1Dgk	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6	MGI:6273512
cn4	Kras^tm5Tyj/Kras⁺ Trp53^tm1.1Dgk/Trp53^tm1.1Dgk	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	MGI:5306615

Allelic Composition	Trp53^tm1Tyj/Trp53^tm1.1Dgk
Genetic Background	involves: 129S * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1.1Dgk mutation (1 available); any Trp53 mutation (235 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (235 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased cell proliferation ( J:180576 )

• in mouse embryonic fibroblasts transfected with a flpo-expressing adenovirus

delayed cellular replicative senescence ( J:180576 )

• in mouse embryonic fibroblasts transfected with a flpo-expressing adenovirus

Allelic Composition	Kras^tm5Tyj/Kras⁺ Pdx1^{tm1.1(flpo)Most}/Pdx1⁺ Trp53^tm1.1Dgk/Trp53⁺
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm5Tyj mutation (2 available); any Kras mutation (83 available)
Pdx1^{tm1.1(flpo)Most} mutation (0 available); any Pdx1 mutation (35 available)
Trp53^tm1.1Dgk mutation (1 available); any Trp53 mutation (235 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:248550 )

• mice exhibit a decrease in median survival time which is approximately 4.5 months of age

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs with only 2 mice showing liver metastasis

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• both low and high grade PanIN lesions are seen at 2-3 months of age, but by 6 months, invasive carcinoma is present

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs with only 2 mice showing liver metastasis

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• both low and high grade PanIN lesions are seen at 2-3 months of age, but by 6 months, invasive carcinoma is present

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:248550

Allelic Composition	Kras^tm5Tyj/Kras⁺ Pdx1^{tm1.1(flpo)Most}/Pdx1⁺ Trp53^tm1.1Dgk/Trp53^tm1.1Dgk
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:248550 )

• mice exhibit a decrease in median survival time which is approximately 2 months of age

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• mice develop classical PanIN lesions that progress to invasive carcinoma

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• mice develop classical PanIN lesions that progress to invasive carcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:248550

Allelic Composition	Kras^tm5Tyj/Kras⁺ Trp53^tm1.1Dgk/Trp53^tm1.1Dgk
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm5Tyj mutation (2 available); any Kras mutation (83 available)
Trp53^tm1.1Dgk mutation (1 available); any Trp53 mutation (235 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor growth/size ( J:180576 )

• lung tumors from mice injected with cre- and flpo-expressing adenoviruses exhibit a doubling time of 2 weeks

increased lung adenocarcinoma incidence ( J:180576 )

• high-grade ling adenocarcinomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses

increased sarcoma incidence ( J:180576 )

• extremity sarcomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses

respiratory system

increased lung adenocarcinoma incidence ( J:180576 )

• high-grade ling adenocarcinomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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