All Phenotypes Trp53<tm1.1Dgk> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53^tm1.1Dgk
targeted mutation 1.1, David G Kirsch
MGI:5306612

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Trp53^tm1Tyj/Trp53^tm1.1Dgk	involves: 129S * 129X1/SvJ * C57BL/6	MGI:5306614
cn2	Kras^tm5Tyj/Kras⁺ Pdx1^{tm1.1(flpo)Most}/Pdx1⁺ Trp53^tm1.1Dgk/Trp53⁺	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6	MGI:6273511
cn3	Kras^tm5Tyj/Kras⁺ Pdx1^{tm1.1(flpo)Most}/Pdx1⁺ Trp53^tm1.1Dgk/Trp53^tm1.1Dgk	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6	MGI:6273512
cn4	Kras^tm5Tyj/Kras⁺ Trp53^tm1.1Dgk/Trp53^tm1.1Dgk	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	MGI:5306615

Allelic Composition	Trp53^tm1Tyj/Trp53^tm1.1Dgk
Genetic Background	involves: 129S * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1.1Dgk mutation (1 available); any Trp53 mutation (240 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased cell proliferation ( J:180576 )

• in mouse embryonic fibroblasts transfected with a flpo-expressing adenovirus

delayed cellular replicative senescence ( J:180576 )

• in mouse embryonic fibroblasts transfected with a flpo-expressing adenovirus

Allelic Composition	Kras^tm5Tyj/Kras⁺ Pdx1^{tm1.1(flpo)Most}/Pdx1⁺ Trp53^tm1.1Dgk/Trp53⁺
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm5Tyj mutation (2 available); any Kras mutation (84 available)
Pdx1^{tm1.1(flpo)Most} mutation (0 available); any Pdx1 mutation (35 available)
Trp53^tm1.1Dgk mutation (1 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:248550 )

• mice exhibit a decrease in median survival time which is approximately 4.5 months of age

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs with only 2 mice showing liver metastasis

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• both low and high grade PanIN lesions are seen at 2-3 months of age, but by 6 months, invasive carcinoma is present

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs with only 2 mice showing liver metastasis

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• both low and high grade PanIN lesions are seen at 2-3 months of age, but by 6 months, invasive carcinoma is present

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:248550

Allelic Composition	Kras^tm5Tyj/Kras⁺ Pdx1^{tm1.1(flpo)Most}/Pdx1⁺ Trp53^tm1.1Dgk/Trp53^tm1.1Dgk
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:248550 )

• mice exhibit a decrease in median survival time which is approximately 2 months of age

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• mice develop classical PanIN lesions that progress to invasive carcinoma

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• mice develop classical PanIN lesions that progress to invasive carcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:248550

Allelic Composition	Kras^tm5Tyj/Kras⁺ Trp53^tm1.1Dgk/Trp53^tm1.1Dgk
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm5Tyj mutation (2 available); any Kras mutation (84 available)
Trp53^tm1.1Dgk mutation (1 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor growth/size ( J:180576 )

• lung tumors from mice injected with cre- and flpo-expressing adenoviruses exhibit a doubling time of 2 weeks

increased lung adenocarcinoma incidence ( J:180576 )

• high-grade ling adenocarcinomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses

increased sarcoma incidence ( J:180576 )

• extremity sarcomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses

respiratory system

increased lung adenocarcinoma incidence ( J:180576 )

• high-grade ling adenocarcinomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24