Analysis Tools|
Allele Symbol Allele Name Allele ID |
Grhl3tm3.1Jane targeted mutation 3.1, Stephen M Jane MGI:5306651 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all die within 7 weeks of tamoxifen treatment
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• regression of skin barrier function after tamoxifen treatment
• dye penetration is variegated matching the pattern of cre mediated gene deletion
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• after tamoxifen treatment gross abnormalities and increased fragility are seen
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• after tamoxifen treatment
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• regression of skin barrier function after tamoxifen treatment
• dye penetration is variegated matching the pattern of cre mediated gene deletion
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• authors state that mice exhibit a phenotype identical to Grhl3tm1Jane/Grhl3tm3.1Jane Tg(KRT14-cre)8Brn mice
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• authors state that mice exhibit a phenotype identical to Grhl3tm1Jane/Grhl3tm3.1Jane Tg(KRT14-cre)8Brn mice
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• authors state that mice exhibit a phenotype identical to Grhl3tm1Jane/Grhl3tm3.1Jane Tg(KRT14-cre)8Brn mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• from E18.5 through 8 weeks, mice exhibit normal skin barrier formation
(J:178952)
• no overt skin barrier defect or abnormality of the cornified envelope of the stratum corneum from birth to 6 weeks of age
(J:233531)
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• in aged mice
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• spontaneously in aged mice affecting the snout and neck
• in 4 weeks after DMBA/TPA treatment
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• spontaneously in aged mice affecting the snout and neck
• in 4 weeks after DMBA/TPA treatment
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• 4 weeks after DMBA/TPA treatment, mice develop skin papillomas many which progress to squamous cell carcinomas unlike control mice
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• spontaneously in aged mice affecting the snout and neck
• in 4 weeks after DMBA/TPA treatment
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• spontaneously in aged mice affecting the snout and neck
• in 4 weeks after DMBA/TPA treatment
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• 4 weeks after DMBA/TPA treatment, mice develop skin papillomas many which progress to squamous cell carcinomas unlike control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• present in expected numbers at E18.5 but all died by P3 with most lost during the first 48 hours after birth
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• at P2 excessive fluid loss and regression of skin barrier function leads to dehydration and death
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• loss of cornified envelope integrity by P2
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• at P2 excessive fluid loss and regression of skin barrier function leads to dehydration and death
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• present in expected numbers at E18.5 and 6 weeks of age
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| N |
• no evidence of skin barrier dysfunction was seen
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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