mortality/aging
• pre-mid-gestation lethality
(J:180729)
• mice die before E9.5
(J:180733)
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Allele Symbol Allele Name Allele ID |
Col3a1m1Lsmi mutation 1, Lee Smith MGI:5306912 |
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Summary |
4 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• pre-mid-gestation lethality
(J:180729)
• mice die before E9.5
(J:180733)
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• median life expectancy is 6 weeks due to aortic dissection
(J:180729)
• some mice exhibit spontaneous aortic dissection resulting in death between 4 and 10 weeks of age
(J:180733)
• more male mice are affected than female mice
(J:180733)
|
• the elastic lamellar exhibit reduced electron density with variable width and disrupted architecture compared with wild-type mice
|
• tearing
|
• most mice that develop spontaneous aortic dissection die between 4 and 10 weeks of age
(J:180733)
|
• at 4, 8, and 12 weeks of age
• however, systolic blood pressure at 14 weeks is normal
|
• in response to 5-hydroxytryptamine
• however, denuded aorta exhibit normal constriction in response to 5-hydroxytryptamine
|
• intact aortas exhibit increased contractile response to 5-hydroxytryptamine compared with wild-type aorta
• however, aortic relaxation in response to acetylcholine and sodium nitroprusside is normal
|
• tearing
|
• in response to 5-hydroxytryptamine
• however, denuded aorta exhibit normal constriction in response to 5-hydroxytryptamine
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
vascular type Ehlers-Danlos syndrome | DOID:14756 |
OMIM:130050 |
J:180733 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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