Phenotypes associated with this allele

• Allele Symbol: Tg(Thy1-GLRA1*R271Q)382Wha
• Allele Name: transgene insertion 382, Hans Weiher
• Allele ID: MGI:5306914
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Thy1-GLRA1*R271Q)382Wha/Tg(Thy1-GLRA1*R271Q)382Wha	involves: C57BL/6 * DBA/2	MGI:5306916
tg2	Tg(Thy1-GLRA1*R271Q)382Wha/0	involves: C57BL/6 * DBA/2	MGI:5306915

Genotype
MGI:5306916

tg1

• Allelic Composition: Tg(Thy1-GLRA1*R271Q)382Wha/Tg(Thy1-GLRA1*R271Q)382Wha
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired righting response ( J:76009 )

• onset at ~2 weeks of age

hyperekplexia ( J:76009 )

• onset at ~2 weeks of age

limb grasping ( J:76009 )

• clench hind feet when lifted by the tail from ~2 weeks of age

tremors ( J:76009 )

• exhibit spontaneous and handling-induced 25-30 Hz tremors with onset at ~2 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hyperekplexia 1		DOID:0060696	OMIM:149400	J:76009

Genotype
MGI:5306915

tg2

• Allelic Composition: Tg(Thy1-GLRA1*R271Q)382Wha/0
• Genetic Background: involves: C57BL/6 * DBA/2

normal phenotype

no abnormal phenotype detected ( J:76009 )

• in contrast with mice hemizygous for Tg(Thy1-GLRA1*R271Q)300Wha, hemizygotes for the present transgene exhibit no overt abnormalities