Phenotypes associated with this allele

• Allele Symbol: Tg(H2-D^b)2Bujf
• Allele Name: transgene insertion 2, Jean-Francois Bureau
• Allele ID: MGI:5306998
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(H2-D^b)2Bujf/0	FVB/NPas-Tg(H2-D^b)2Bujf	MGI:5306999

Genotype
MGI:5306999

tg1

• Allelic Composition: Tg(H2-D^b)2Bujf/0
• Genetic Background: FVB/NPas-Tg(H2-D^b)2Bujf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to Picornaviridae infection ( J:18556 )

• mice bearing this transgene are resistant to persistent infection of the central nervous system by Theiler's murine encephalomyelitis virus (TMEV); 45 days after intracranial inoculation, when longitudinal sections of the spinal cords of their non-transgenic littermates exhibit definite, usually intense focal inflammation of white matter, perivascular cuffs, parenchymal infiltration of mononuclear cells, meningitis and numerous infected cells (identified by polyclonal antiserum vs. TMEV capsid antigens), spinal cords of transgenic animals exhibit few or no cells containing viral antigens and no or minimal inflammation