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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Card11tm1.1Litt
targeted mutation 1.1, Dan R Littman
MGI:5307006
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Card11tm1.1Litt/Card11tm1.1Litt
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Tg(TcraTcrb)425Cbn/? 		involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6 MGI:5307048
cn2
 		Card11tm1.1Litt/Card11tm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+ 		involves: 129P2/OlaHsd * 129X1/SvJ MGI:5307043


Genotype
MGI:5307048
cn1
Allelic
Composition		 Card11tm1.1Litt/Card11tm1.1Litt
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Tg(TcraTcrb)425Cbn/?
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11tm1.1Litt mutation (0 available); any Card11 mutation (59 available)
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell activation ( J:180410 )
• reactivation is prevented after in vitro activation with Ova and tamoxifen treatment

hematopoietic system
abnormal T cell activation ( J:180410 )
• reactivation is prevented after in vitro activation with Ova and tamoxifen treatment




Genotype
MGI:5307043
cn2
Allelic
Composition		 Card11tm1.1Litt/Card11tm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11tm1.1Litt mutation (0 available); any Card11 mutation (59 available)
Tnfrsf4tm2(cre)Nik mutation (1 available); any Tnfrsf4 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:180410 )
N
• memory T cell development is unaffected
abnormal T cell activation ( J:180410 )
• impaired "reactivation" of T cells after a second antibody challenge
respiratory system inflammation ( J:180410 )
• decreased cellular infiltration of lungs when rechallenged 6 weeks after initial Ova exposure
• fewer cells in bronchoalveolar lavage fluid
• fewer eosinophiles
• increased number of macrophage
• reduced number of activated T cells after rechallenge (CD4+CD69+)

respiratory system
respiratory system phenotype ( J:180410 )
N
• acute airway response to Ova challenge is unaffected
respiratory system inflammation ( J:180410 )
• decreased cellular infiltration of lungs when rechallenged 6 weeks after initial Ova exposure
• fewer cells in bronchoalveolar lavage fluid
• fewer eosinophiles
• increased number of macrophage
• reduced number of activated T cells after rechallenge (CD4+CD69+)

hematopoietic system
abnormal T cell activation ( J:180410 )
• impaired "reactivation" of T cells after a second antibody challenge




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory