nervous system
• aberrant outgrowth of mossy fibers
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• aberrant outgrowth of mossy fibers
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• most mice die around P20 for unknown reasons
|
N |
• mice exhibit normal granule and cone cell proliferation
|
• at P6 in the dentate gyrus and cortex
|
• at P6
|
• at P6 and 2 months of age, but not P1
|
• dentate granule cells exhibit aberrant outgrowth of mossy fibers into CA3 compared with wild-type cells
• however, transfection of retina with an adenovirus expressing a short-hairpin RNA targeting Lhx2 rescues dentate gyrus axon phenotype
|
• mislocalized
|
• mice exhibit a reduction in cone cells compared with wild-type mice
• however, transfection of retina with an adenovirus expressing a short-hairpin RNA targeting Lhx2 rescues cone cell reduction
|
• at P3
|
• mislocalized
|
• mice exhibit a reduction in cone cells compared with wild-type mice
• however, transfection of retina with an adenovirus expressing a short-hairpin RNA targeting Lhx2 rescues cone cell reduction
|
• reduced amplitude
|
• at 4 and 5 months of age
|
• at P6 in the dentate gyrus and cortex
|
• at P3
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• at 8 weeks of age
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no mice are produced from heterozygotes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• at 8 weeks of age
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• reduction and mislocalization of cone cells observed in A930011O12Rik/Mir124a-1tm1Tfur homozygotes is rescued
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• apoptosis in the dentate gyrus observed in A930011O12Rik/Mir124a-1tm1Tfur homozygotes is rescued
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/21/2024 MGI 6.24 |
![]() |
|