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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir124a-1hgtm1Tfur
targeted mutation 1, Takahisa Furukawa
MGI:5307015
Summary 8 genotypes


Genotype
MGI:7461684
hm1
Allelic
Composition		 Mir124a-1hgtm1Tfur/Mir124a-1hgtm1Tfur
Genetic
Background		 129S6/SvEvTac-Mir124a-1hgtm1Tfur/Tfur
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation (2 available); any Mir124a-1hg mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampal mossy fiber morphology ( J:333877 )
• aberrant outgrowth of mossy fibers




Genotype
MGI:5307049
hm2
Allelic
Composition		 Mir124a-1hgtm1Tfur/Mir124a-1hgtm1Tfur
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation (2 available); any Mir124a-1hg mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:179784 )
• most mice die around P20 for unknown reasons

nervous system
nervous system phenotype ( J:179784 )
N
• mice exhibit normal granule and cone cell proliferation
increased neuron apoptosis ( J:179784 )
• at P6 in the dentate gyrus and cortex
decreased brain weight ( J:179784 )
• at P6 and 2 months of age, but not P1
abnormal hippocampus granule cell morphology ( J:179784 )
• dentate granule cells exhibit aberrant outgrowth of mossy fibers into CA3 compared with wild-type cells
• however, transfection of retina with an adenovirus expressing a short-hairpin RNA targeting Lhx2 rescues dentate gyrus axon phenotype
decreased retina cone cell number ( J:179784 )
• mice exhibit a reduction in cone cells compared with wild-type mice
• however, transfection of retina with an adenovirus expressing a short-hairpin RNA targeting Lhx2 rescues cone cell reduction

vision/eye
decreased retina cone cell number ( J:179784 )
• mice exhibit a reduction in cone cells compared with wild-type mice
• however, transfection of retina with an adenovirus expressing a short-hairpin RNA targeting Lhx2 rescues cone cell reduction
abnormal cone electrophysiology ( J:179784 )
• reduced amplitude

behavior/neurological
limb grasping ( J:179784 )
• at 4 and 5 months of age

cellular
increased neuron apoptosis ( J:179784 )
• at P6 in the dentate gyrus and cortex




Genotype
MGI:7461691
cx3
Allelic
Composition		 Mir124a-1hgtm1Tfur/Mir124a-1hg+
Mir124a-2tm1.1Tfur/Mir124a-2+
Genetic
Background		 129S6/SvEvTac-Mir124a-1hgtm1Tfur Mir124a-2tm1.1Tfur
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation (2 available); any Mir124a-1hg mutation (3 available)
Mir124a-2tm1.1Tfur mutation (1 available); any Mir124a-2 mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system

growth/size/body
postnatal growth retardation ( J:333877 )
• at 8 weeks of age




Genotype
MGI:7461692
cx4
Allelic
Composition		 Mir124a-1hgtm1Tfur/Mir124a-1hgtm1Tfur
Mir124a-2tm1.1Tfur/Mir124a-2tm1.1Tfur
Genetic
Background		 129S6/SvEvTac-Mir124a-1hgtm1Tfur Mir124a-2tm1.1Tfur
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation (2 available); any Mir124a-1hg mutation (3 available)
Mir124a-2tm1.1Tfur mutation (1 available); any Mir124a-2 mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7461694
cx5
Allelic
Composition		 Mir124a-1hgtm1Tfur/Mir124a-1hgtm1Tfur
Mir124a-2tm1.1Tfur/Mir124a-2tm1.1Tfur
Mir124a-3tm1.1Tfur/Mir124a-3tm1.1Tfur
Genetic
Background		 129S6/SvEvTac-Mir124a-1hgtm1Tfur Mir124a-2tm1.1Tfur Mir124a-3tm1.1Tfur
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation (2 available); any Mir124a-1hg mutation (3 available)
Mir124a-2tm1.1Tfur mutation (1 available); any Mir124a-2 mutation (3 available)
Mir124a-3tm1.1Tfur mutation (1 available); any Mir124a-3 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:333877 )
• no mice are produced from heterozygotes




Genotype
MGI:7461696
cx6
Allelic
Composition		 Mir124a-1hgtm1Tfur/Mir124a-1hg+
Mir124a-2tm1.1Tfur/Mir124a-2+
Mir124a-3tm1.1Tfur/Mir124a-3+
Genetic
Background		 129S6/SvEvTac-Mir124a-1hgtm1Tfur Mir124a-2tm1.1Tfur Mir124a-3tm1.1Tfur
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation (2 available); any Mir124a-1hg mutation (3 available)
Mir124a-2tm1.1Tfur mutation (1 available); any Mir124a-2 mutation (3 available)
Mir124a-3tm1.1Tfur mutation (1 available); any Mir124a-3 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:333877 )
• at 8 weeks of age

nervous system




Genotype
MGI:5307046
cx7
Allelic
Composition		 Mir124a-1hgtm1Tfur/Mir124a-1hgtm1Tfur
Tg(Crx-DsRed,-Mir124a-2)#Tfur/0
Genetic
Background		 involves: 129S6/SvEvTac * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation (2 available); any Mir124a-1hg mutation (3 available)
Tg(Crx-DsRed,-Mir124a-2)#Tfur mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:179784 )
N
• reduction and mislocalization of cone cells observed in A930011O12Rik/Mir124a-1tm1Tfur homozygotes is rescued




Genotype
MGI:5307044
cx8
Allelic
Composition		 Mir124a-1hgtm1Tfur/Mir124a-1hgtm1Tfur
Tg(Syn1-DsRed,-Mir124a-2)#Tfur/0
Genetic
Background		 involves: 129S6/SvEvTac * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation (2 available); any Mir124a-1hg mutation (3 available)
Tg(Syn1-DsRed,-Mir124a-2)#Tfur mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:179784 )
N
• apoptosis in the dentate gyrus observed in A930011O12Rik/Mir124a-1tm1Tfur homozygotes is rescued




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory