Phenotypes associated with this allele

• Allele Symbol: Cacng8^tm1.1Suto
• Allele Name: targeted mutation 1.1, Susumu Tomita
• Allele ID: MGI:5307062
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacng8^tm1.1Suto/Cacng8^tm1.1Suto	Not Specified	MGI:5307142
cx2	Cacng2^stg/Cacng2^stg Cacng8^tm1.1Suto/Cacng8^tm1.1Suto	involves: A/J	MGI:5307143

Genotype
MGI:5307142

hm1

• Allelic Composition: Cacng8^tm1.1Suto/Cacng8^tm1.1Suto
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:179775 )

N • mice are viable

reproductive system

abnormal reproductive system physiology ( J:179775 )

• mice exhibit difficulty breeding when using homozygotes

nervous system

nervous system phenotype ( J:179775 )

N • mice exhibit normal paired-pulse ratio and long term potentiation

abnormal excitatory postsynaptic currents ( J:179775 )

• the ratio of AMPAR-mediated to NMDAR-mediated excitatory postsynaptic currents is reduced compared to in wild-type mice

abnormal glutamate-mediated receptor currents ( J:179775 )

• the ratio of AMPAR-mediated to NMDAR-mediated excitatory postsynaptic currents is reduced compared to in wild-type mice

abnormal AMPA-mediated synaptic currents ( J:179775 )

• the AMPA-evoked whole-cell currents are reduced compared to in wild-type mice

• however, mice exhibit normal I-V relationship of synaptic AMPARs

Genotype
MGI:5307143

cx2

• Allelic Composition: Cacng2^stg/Cacng2^stg; Cacng8^tm1.1Suto/Cacng8^tm1.1Suto
• Genetic Background: involves: A/J

mortality/aging

premature death ( J:179775 )

• most die by P28

growth/size/body

postnatal growth retardation ( J:179775 )

• severe