Phenotypes associated with this allele

• Allele Symbol: Uqcrfs1^tm1.1Hek
• Allele Name: targeted mutation 1.1, Siegfried Hekimi
• Allele ID: MGI:5307154
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Uqcrfs1^tm1.1Hek/Uqcrfs1^tm1.1Hek	involves: C57BL/6	MGI:5307156
ht2	Uqcrfs1^tm1.1Hek/Uqcrfs1^+	involves: C57BL/6	MGI:5307157

Genotype
MGI:5307156

hm1

• Allelic Composition: Uqcrfs1^tm1.1Hek/Uqcrfs1^tm1.1Hek
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:179765 )

• no mice are produced

Genotype
MGI:5307157

ht2

• Allelic Composition: Uqcrfs1^tm1.1Hek/Uqcrfs1⁺
• Genetic Background: involves: C57BL/6

mortality/aging

abnormal survival ( J:179765 )

• as determined by Gompertz mortality parameters, the rate of increase of mortality with age is decreased and the intrinsic vulnerability to death, particularly in male mice, is increased compared to in wild-type mice

extended life span ( J:179765 )

• remaining survival of female mice that live beyond median survival is increased compared with similar wild-type female mice

premature death ( J:179765 )

• the lifespan of male mice is 10% less than in wild-type mice

cellular

abnormal respiratory electron transport chain ( J:179765 )

• mice exhibit a substrate-dependent decreased liver mitochondrial respiration (complex III enzymatic activity) compared with wild-type mice

homeostasis/metabolism

decreased basal metabolism ( J:179765 )

• lowered in young mice

behavior/neurological

behavior/neurological phenotype ( J:179765 )

N • young mice exhibit normal motor coordination, motor learning and running speed