Phenotypes associated with this allele

• Allele Symbol: Tg(Lgi1)#Mpan
• Allele Name: transgene insertion, Matthew P Anderson
• Allele ID: MGI:5307226
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Lgi1)#Mpan/0	Not Specified	MGI:5307229

Genotype
MGI:5307229

tg1

• Allelic Composition: Tg(Lgi1)#Mpan/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon pruning ( J:154129 )

• mature granule cells develop a shortened apical dendritic arbor compared to wild-type mice, indicating excessive pruning of dendrites compared to controls

abnormal dendrite morphology ( J:154129 )

• mature granule cells develop a shortened apical dendritic arbor compared to wild-type mice, indicating excessive pruning of dendrites compared to controls

abnormal synaptic transmission ( J:154129 )

• the decrease in hippocampal medial perforant path (MPP) release probability (presynaptic function) with maturation that normally happens in wild-type mice is amplified in mutants

decreased excitatory postsynaptic current amplitude ( J:154129 )

• amplitude of AMPA receptor-mediated and NMDA receptor-mediated EPSCs, and the frequency of miniature EPSCs are lower in brain slices from mutants than controls

abnormal miniature excitatory postsynaptic currents ( J:154129 )

• the frequency of miniature EPSCs are lower in brain slices from mutants than controls

abnormal paired-pulse facilitation ( J:154129 )

• glutamatergic synapses show persistent facilitation and a larger augmentation with repeated stimulation compared to wild-type mice which show neither facilitation nor depression and moderate augmentation

cellular

abnormal axon pruning ( J:154129 )

• mature granule cells develop a shortened apical dendritic arbor compared to wild-type mice, indicating excessive pruning of dendrites compared to controls