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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfsf11tles
toothless
MGI:5307891
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfsf11tles/Tnfsf11tles involves: 129S6/SvEvTac * C57BL/6J MGI:5307894
ht2
 		Tnfsf11tles/Tnfsf11tm1Pngr involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J MGI:5307895
cx3
 		Tg(TNFSF11)5516Edou/0
Tnfsf11tles/Tnfsf11tles 		involves: 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5788434
cx4
 		Tg(TNFSF11)5519Edou/0
Tnfsf11tles/Tnfsf11tles 		involves: 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5788435


Genotype
MGI:5307894
hm1
Allelic
Composition		 Tnfsf11tles/Tnfsf11tles
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf11tles mutation (2 available); any Tnfsf11 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:179743 )
• most mice die by the seventh week of age

skeleton
skeleton phenotype ( J:179743 )
N
• bone marrow exposed to wild-type osteoblasts exhibits normal differentiation into osteoclasts
abnormal osteoblast physiology ( J:179743 )
• in culture, osteoblasts fail to produce adequate crosstalk to promote differentiation of wild-type hematopoietic progenitors into osteoclasts
decreased osteoclast cell number ( J:179743 )
• absent
• however, treatment with TNFSF11 restores osteoclast formation
abnormal trabecular bone morphology ( J:179743 )
• trabecular spacing is reduced compared to in wild-type mice
osteopetrosis ( J:179743 )
• severe

immune system
decreased osteoclast cell number ( J:179743 )
• absent
• however, treatment with TNFSF11 restores osteoclast formation

growth/size/body
failure of tooth eruption ( J:179743 )
postnatal growth retardation ( J:179743 )
enlarged spleen ( J:179743 )

craniofacial

hematopoietic system
decreased osteoclast cell number ( J:179743 )
• absent
• however, treatment with TNFSF11 restores osteoclast formation

endocrine/exocrine glands

cellular
abnormal osteoblast physiology ( J:179743 )
• in culture, osteoblasts fail to produce adequate crosstalk to promote differentiation of wild-type hematopoietic progenitors into osteoclasts

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
autosomal recessive osteopetrosis 2 DOID:0110943 OMIM:259710
 J:179743




Genotype
MGI:5307895
ht2
Allelic
Composition		 Tnfsf11tles/Tnfsf11tm1Pngr
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf11tles mutation (2 available); any Tnfsf11 mutation (32 available)
Tnfsf11tm1Pngr mutation (0 available); any Tnfsf11 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal trabecular bone morphology ( J:179743 )
• trabecular spacing is reduced compared to in wild-type mice
osteopetrosis ( J:179743 )
• severe

immune system

craniofacial

hematopoietic system

growth/size/body
failure of tooth eruption ( J:179743 )




Genotype
MGI:5788434
cx3
Allelic
Composition		 Tg(TNFSF11)5516Edou/0
Tnfsf11tles/Tnfsf11tles
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TNFSF11)5516Edou mutation (0 available)
Tnfsf11tles mutation (2 available); any Tnfsf11 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal tooth eruption ( J:233240 )
• mice show rescue of lower incisor eruption but only partial rescue of upper incisor eruption

immune system
absent lymph nodes ( J:233240 )
• mice show failure of lymph node organogenesis

growth/size/body
abnormal tooth eruption ( J:233240 )
• mice show rescue of lower incisor eruption but only partial rescue of upper incisor eruption

mortality/aging
mortality/aging ( J:233240 )
N
• mice exhibit normal survival

skeleton
skeleton phenotype ( J:233240 )
N
• mice exhibit rescue of the osteopetrotic phenotype seen in single Tnfsf11tles homozygotes
abnormal tooth eruption ( J:233240 )
• mice show rescue of lower incisor eruption but only partial rescue of upper incisor eruption




Genotype
MGI:5788435
cx4
Allelic
Composition		 Tg(TNFSF11)5519Edou/0
Tnfsf11tles/Tnfsf11tles
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TNFSF11)5519Edou mutation (0 available)
Tnfsf11tles mutation (2 available); any Tnfsf11 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:233240 )
• mice exhibit complete rescue of the abnormal phenotypes seen in single Tnfsf11tles homozygotes, including rescue of the osteopetrotic phenotype, of both lower and upper incisor eruption defects and of mesenteric lymph node organogenesis




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory