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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(RAC1*)Jkis
targeted mutation 1, Joseph L Kissil
MGI:5307896
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(RAC1*)Jkis/Gt(ROSA)26Sor+ involves: 129 MGI:5437471
cn2
 		Gt(ROSA)26Sortm1(RAC1*)Jkis/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+ 		involves: 129S4/SvJae MGI:5437472


Genotype
MGI:5437471
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(RAC1*)Jkis/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(RAC1*)Jkis mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:187582 )
N
• mice treated with a cre-expressing adenovirus exhibit no hyperplasia or tumors in the lungs




Genotype
MGI:5437472
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(RAC1*)Jkis/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(RAC1*)Jkis mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor growth/size ( J:187582 )
• mice treated with a cre-expressing adenovirus exhibit increased tumor burden due to increased lung cancer cell proliferation compared with Krastm4Tyj heterozygotes treated with a cre-expressing adenovirus
increased lung adenocarcinoma incidence ( J:187582 )
• in mice treated with a cre-expressing adenovirus

respiratory system
increased lung adenocarcinoma incidence ( J:187582 )
• in mice treated with a cre-expressing adenovirus




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory