Phenotypes associated with this allele

• Allele Symbol: Npy1r^tm1.1Ceva
• Allele Name: targeted mutation 1.1, Carola Eva
• Allele ID: MGI:5307897
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Npy1r^tm1.1Ceva/Npy1r^tm1.1Ceva Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-cre)LC1Bjd/0	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL	MGI:5307910

Genotype
MGI:5307910

cn1

• Allelic Composition: Npy1r^tm1.1Ceva/Npy1r^tm1.1Ceva; Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-cre)LC1Bjd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased subcutaneous adipose tissue amount ( J:180396 )

• Background Sensitivity: in doxycycline-treated mice raised by FVB/J

• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight

decreased epididymal fat pad weight ( J:180396 )

• Background Sensitivity: in doxycycline-treated mice raised by FVB/J

• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight

decreased total fat pad weight ( J:180396 )

• Background Sensitivity: visceral, epididymal and subcutaneous white adipose tissue in doxycycline-treated mice raised by FVB/J

• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight

homeostasis/metabolism

increased circulating corticosterone level ( J:180396 )

• Background Sensitivity: in doxycycline-treated mice raised by FVB/J

• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal leptin levels

decreased circulating leptin level ( J:180396 )

• Background Sensitivity: in doxycycline-treated mice raised by FVB/J

• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal leptin levels

behavior/neurological

increased anxiety-related response ( J:180396 )

• Background Sensitivity: in an elevated plus maze and open field test, doxycycline-treated mice raised by FVB/J dams exhibit increased anxiety-related behaviors compared with similarly fostered control mice

• however, doxycycline-treated mice fostered by C57BL/6J dams exhibit normal anxiety

decreased locomotor activity ( J:180396 )

• doxycycline-treated mice raised by C57BL/6J dams exhibit decreased total distance traveled in an open field compared with control mice and doxycycline-treated mice raised by FVB/J dams

growth/size/body

slow postnatal weight gain ( J:180396 )

• after doxycycline treatment at P41 and P48, mice raised by FVB/J dams, and to a lesser extent raised by C57BL/6J dams, exhibit slower body weight gain compared with control mice

integument

decreased subcutaneous adipose tissue amount ( J:180396 )

• Background Sensitivity: in doxycycline-treated mice raised by FVB/J

• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight