Phenotypes associated with this allele

• Allele Symbol: Rgs18^m1H
• Allele Name: mutation 1, Harwell
• Allele ID: MGI:5307901
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgs18^m1H/Rgs18^m1H	BALB/cAnN-Rgs18^m1H/H	MGI:5751788

Genotype
MGI:5751788

hm1

• Allelic Composition: Rgs18^m1H/Rgs18^m1H
• Genetic Background: BALB/cAnN-Rgs18^m1H/H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal hemostasis ( J:228457 )

• homozygotes display enhanced hemostasis responses relative to wild-type controls

increased platelet aggregation ( J:228457 )

• in vitro, platelets show enhanced agonist-induced aggregation in response to thrombin (0.025-0.1 U/ml) and to the thromboxane receptor agonist U46619 (0.5 uM)

• the dose-response curve for in vitro platelet aggregation induced by thrombin and U46619 is shifted to the left

increased susceptibility to induced thrombosis ( J:228457 )

• in the Fecl3 carotid artery thrombosis model, homozygotes (8-10 weeks old) show a significantly shortened occlusion time relative to wild-type controls

decreased bleeding time ( J:228457 )

• homozygotes show a significantly shortened tail bleeding time relative to wild-type controls

hematopoietic system

increased platelet aggregation ( J:228457 )

• in vitro, platelets show enhanced agonist-induced aggregation in response to thrombin (0.025-0.1 U/ml) and to the thromboxane receptor agonist U46619 (0.5 uM)

• the dose-response curve for in vitro platelet aggregation induced by thrombin and U46619 is shifted to the left