Phenotypes associated with this allele

• Allele Symbol: Pdk4^tm1Tok
• Allele Name: targeted mutation 1, Toshihisa Komori
• Allele ID: MGI:5307906
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdk4^tm1Tok/Pdk4^tm1Tok	B6.129P2-Pdk4^tm1Tok	MGI:5307907

Genotype
MGI:5307907

hm1

• Allelic Composition: Pdk4^tm1Tok/Pdk4^tm1Tok
• Genetic Background: B6.129P2-Pdk4^tm1Tok

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast morphology ( J:179789 )

• osteoclast surface and eroded surface remain normal after one week of tail suspension in contrast to controls

abnormal osteoclast differentiation ( J:179789 )

• progression from bone marrow macrophage to large and giant osteoclast is reduced

abnormal osteoclast cell number ( J:179789 )

• remains normal after one week of tail suspension in contrast to controls

abnormal bone volume ( J:179789 )

• bone volume remains normal after one week of tail suspension in contrast to controls

abnormal trabecular bone morphology ( J:179789 )

abnormal trabecular bone volume ( J:179789 )

• remains normal after one week of tail suspension in contrast to controls

abnormal trabecular bone thickness ( J:179789 )

• remains normal after one week of tail suspension in contrast to controls

hematopoietic system

abnormal osteoclast morphology ( J:179789 )

• osteoclast surface and eroded surface remain normal after one week of tail suspension in contrast to controls

abnormal osteoclast differentiation ( J:179789 )

• progression from bone marrow macrophage to large and giant osteoclast is reduced

abnormal osteoclast cell number ( J:179789 )

• remains normal after one week of tail suspension in contrast to controls

immune system

abnormal osteoclast morphology ( J:179789 )

• osteoclast surface and eroded surface remain normal after one week of tail suspension in contrast to controls

abnormal osteoclast differentiation ( J:179789 )

• progression from bone marrow macrophage to large and giant osteoclast is reduced

abnormal osteoclast cell number ( J:179789 )

• remains normal after one week of tail suspension in contrast to controls

cellular

abnormal osteoclast differentiation ( J:179789 )

• progression from bone marrow macrophage to large and giant osteoclast is reduced