Phenotypes associated with this allele

• Allele Symbol: Esco2^tm1.1Ge
• Allele Name: targeted mutation 1.1, Gregor Eichele
• Allele ID: MGI:5308062
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Esco2^tm1.1Ge/Esco2^tm1.1Ge Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S2/SvPas * C57BL/6 * CBA * SJL	MGI:5308067
cn2	Emx1^tm1(cre)Krj/Emx1^+ Esco2^tm1.1Ge/Esco2^tm1.1Ge	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:5308068
cn3	Esco2^tm1.1Ge/Esco2^tm1.1Ge Ndor1^Tg(UBC-cre/ERT2)1Ejb/Ndor1^+	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:6828779

Genotype
MGI:5308067

cn1

• Allelic Composition: Esco2^tm1.1Ge/Esco2^tm1.1Ge; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell nucleus morphology ( J:180371 )

• tamoxifen-treated mouse embryonic fibroblasts exhibit highly abnormal nuclear morphology with micronuclei and multilobulated nuclei

abnormal chromosome morphology ( J:180371 )

• chromosomes from tamoxifen-treated mouse embryonic fibroblasts exhibit railroad track morphology

abnormal mitosis ( J:180371 )

• tamoxifen-treated mouse embryonic fibroblasts exhibit lagging chromosomes with reduced pericentric heterochromatin cohesion

increased mitotic index ( J:180371 )

• tamoxifen-treated mouse embryonic fibroblasts exhibit a 2.5-fold increase in mitotic index in asynchronously grown cultures

decreased cell proliferation ( J:180371 )

• tamoxifen-treated mouse embryonic fibroblasts fail to proliferate

Genotype
MGI:5308068

cn2

• Allelic Composition: Emx1^tm1(cre)Krj/Emx1⁺; Esco2^tm1.1Ge/Esco2^tm1.1Ge
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

nervous system

increased neuron apoptosis ( J:180371 )

• of neuronal progenitor cells in the ventricular zone

abnormal neuronal precursor proliferation ( J:180371 )

• 2-fold increase in the number of mitotic cells at E11.25 in the neuroepithelium of the neocortex but not of the ganglionic eminence

abnormal embryonic neuroepithelium morphology ( J:180371 )

• nearly complete agenesis of the neocortical and hippocampal neuroepithelium at E12.5

abnormal hippocampus development ( J:180371 )

• reduced hippocampal primordium at E11.25

• nearly complete agenesis of the neocortical and hippocampal neuroepithelium at E12.5

absent hippocampus ( J:180371 )

• in adult mice

abnormal neocortex morphology ( J:180371 )

• nearly complete agenesis of the neocortical and hippocampal neuroepithelium at E12.5

• neuroepithelium at E12.5

• adult mice lack most of the cortex

embryo

abnormal embryonic neuroepithelium morphology ( J:180371 )

• nearly complete agenesis of the neocortical and hippocampal neuroepithelium at E12.5

cellular

increased neuron apoptosis ( J:180371 )

• of neuronal progenitor cells in the ventricular zone

abnormal neuronal precursor proliferation ( J:180371 )

• 2-fold increase in the number of mitotic cells at E11.25 in the neuroepithelium of the neocortex but not of the ganglionic eminence

growth/size/body

microcephaly ( J:180371 )

• severe

Genotype
MGI:6828779

cn3

• Allelic Composition: Esco2^tm1.1Ge/Esco2^tm1.1Ge; Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/Ndor1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

cellular

abnormal mitosis ( J:296958 )

• tamoxifen-treated mouse embryonic fibroblasts arrest in S-phase